Refractory RLS Study

[Joolsg]

sciencedirect.com/science/a...

A new study on refractory RLS recommends NOT starting young patients on dopamine agonists.

Hopefully, we will start to see more and more of these studies and they will condemn the use of dopamine agonists.

[amrob123]

Too late for me Jools! 😲I haven't opened the full article but was interested to read that it concludes that:

"Botulinum toxin is an effective second-line treatment for RLS."

[707twitcher in reply to amrob123]

That caught my eye, too. Looks like there were some studies done, but they seem to be circa 2007. Anyone here tried Botox for RLS? Likely to be expensive, not covered by insurance, and good luck finding someone who has done this before and knows which muscles to inject. Still, I'm intrigued....

[ChrisColumbus in reply to 707twitcher]

But this 2012 study, quoted in the references to the above 2024 paper, ended:"In conclusion, our results show no indication for a BoNT/A (intradermally injected botulinum neurotoxin type A) treatment benefit in RLS..."

sciencedirect.com/science/a...

[ChrisColumbus in reply to 707twitcher]

On the other hand this 2017 study concludes that:"BoNT (botulinum neurotoxin) is a safe and effective treatment in a variety of movement disorders, but better understanding is needed as to its peripheral and central mechanisms."

doi.org/10.1016/j.toxicon.2...

[SueJohnson]

I have this in my notes Botox injections at the applied dose can reduce the severity of symptoms in RLS up to 6 weeks. Moreover, the quality of life of the RLS patient can be improved for up to 6 weeks post-injection, and pain and discomfort diminished for 4 weeks." according to a placebo controlled study. Injections were into the tibialis anterior, gastrocnemius, and hamstring muscle each side.

Source: neurologylive.com/view/botu... and sciencedirect.com/science/a... which sites a number of articles

[HipHop1972]

it’s a start and mighty oaks grow from little acorns. Thanks for sharing Joolsg

HipHop1972