buprenorphine & LDN

[707twitcher]

I feel like an idiot 😱. I thought that I was having augmentation-like issues with buprenorphine. I had overlooked the fact that I started taking LDN (low dose naltrexone; 4.5mg dose) a few days ago after reading about some people getting results from it for RLS. (I had the LDN around because I used to take it for several years for inflammation, sleep, energy, etc.)

I assume that the LDN is at least partially blocking the opioid effect - which is what it is meant to do when treating overdoses. So I assume anyone getting results from LDN for RLS must not be taking it with opioids.

Sorry if I panicked anyone with my earlier post about augmentation….

[Joolsg]

That's worrying. I've been on the same low dose for over 3 years.Perhaps it is the steroid eye drops. You can monitor over the next few weeks, as you reduce/stop the eye drops.

[RiversW]

Twitcher, I hope for you that there is another explanation aside from the Buprenorphine. I have been taking Buprenorphine for 4 months. I have yet to settle on the right delivery method or dose so you can probably take my comments with a grain of salt. On more than one occasion whether with the patch or tablet I have had to up my dose to cover symptoms. With the patch, even after settling on what seemed to be the right dose, I had what appeared to be breakthrough symptoms, but for only a couple of nights and then back to normal. With the tablets, when I had the same experience, I upped my dose and then lowered again after a couple of weeks with good results.

I hope this information is useful to you if only to confirm that I may not be a good source of solid data. Take care and good luck. Rivers

[Joolsg]

LDN can't be taken with opioids. You first have to titrate off the opioid.Here in the UK, LDN is only available from a few private clinics on a private prescription and they won't prescribe it to anyone on opioids.

[amrob123]

Definitely not to be taken together. From an LDN Facebook group:"If you have been on regular opiate doses (including Tramadol) you cannot add LDN to your routine without risk of precipitated and potentially dangerous withdrawal as well as increased pain. Precipitated withdrawal from taking naltrexone may develop within minutes. It can to last up to 48 hours."

It would appear that the increased symptoms were actually the result of buprenorphine withdrawal.