Wellbutrin and RLS

[Sahhara]

Hello everyone. Are there any people here who have been helped by wellbutrin?

[SueJohnson]

Wellbutrin is good for depression but won't help symptoms of RLS. How much pregabalin are you taking? Are you taking any other medicines or over the counter supplements. If you list them here, I can tell you whether any of them are making your RLS worse and can perhaps provide you with a safe substitute.

[Canterberry in reply to SueJohnson]

Sue, what about 5HTP?

[SueJohnson in reply to Canterberry]

It helps with sleep and may help depression.

[Canterberry in reply to SueJohnson]

Can one take it if using gabapentin and .50 trazadine (for sleep)?

[SueJohnson in reply to Canterberry]

yes

[Canterberry in reply to SueJohnson]

Thank you for you help

[Rezcat11]

Echoing SueJohnson, Wellbutrin does nothing for RLS.

However, it is one of, if not the only, antidepressants that doesn't make RLS worse.

That's why my medication regimen for depression and anxiety consists of daily wellbutrin and lamictal, and monthly ketamine infusions.

[SueJohnson in reply to Rezcat11]

There are other antidepressants that don't make RLS worse although Wellbutrin is probably the best but not available in the UK. Second best is trazodone.

[jaime77 in reply to SueJohnson]

Hey, it is available in the uk but privately and to help you give up smoking, I’ve just paid for a prescription as I’m currently on fluoxetine but want to stop as it’s making my RLS worse

[SueJohnson in reply to jaime77]

Great !

[ircam2112]

Yes. I’ve been on Wellbutrin on and off for a number of years. It’s a particularly a good adjunct/add on medication for another antidepressant. It is a little activating and comes in extended release and immediate release. I take the immediate release in the am and early pm (1pm ) so that it doesn’t create insomnia, restless sleep. It’s the only antidepressant that I’m aware of that usually doesn’t make RLS worse and some studies even show a slight improvement in PLMS at night. Best wishes

[SueJohnson in reply to ircam2112]

See mu reply to Rezcat11.

[LanaCSR in reply to ircam2112]

Very good information and advice, ircam2112!! Glad you're getting help and relief for both problems! 😊

[Sahhara]

Sanks

[utes]

My husband was on Wellbutrin for many years. He had 120 ECTS to help his depression. In the end the non invasive TMS (Transcranial Magnetic Stimulation) did the trick. Wellbutrin did not have any effect on his RLS. After augmenting on DAs he was switched to Methadone.

[Kmoore464]

I take it and have for years for depression. Idk if it affects rls

[Lilcatfeet]

I had a very bad anaphylactic reaction to it. Allergist said it’s not uncommon.

[Canterberry]

I started taking it but it made me very angry and irritable. I had to stop.