Pregabalin problems

[lee_uk]

I’ve been taking Pregablin for nearly a month. 2 weeks on 75mg and now 2 weeks on 150mg. It started off great and could nearly go the whole night. Since a week ago they have completely stopped working and I’m back up about 10/12 times a night. Should I keep at 150mg for a bit longer or try 225mg?

[Heatherlss]

your experience is very similar to mine. When I began using Pregabalin, I could go through an entire night uninterrupted with RLS; however, the relief was for only a week. Its as if my body got adjusted to Pregabalin in a week's time. I took Pregabalin for 5 months before I concluded that it wasn't doing much. I have since switched from Pregab 150mg to Gabapentin 300mg. Again, I don't see much benefit but I do think that Pregab was helping my insomnia because on Gabapentin, I don't sleep so well.

[lee_uk in reply to Heatherlss]

Very strange, I might try 225mg tonight and see if that helps

[Hidden in reply to lee_uk]

Hi, it does take nearly a month to start working fully.

If you've also recently stopped taking a DA, then part of the problem may be withdrawals.

150mg is the minimum effective dose, you may need up to 400mg.

[lee_uk in reply to Hidden]

Ok thanks, I’ll maybe give it a few more days then see if I can’t up it a bit

[Hidden in reply to Heatherlss]

Minimum effective dose of pregabalin is 150mg, but some people may need up to 400mg.

Minimum effective dose of gabapentin is 900mg.

It won't work if you don't take enough.

[wantokporo]

Isn't there the option to go up slower?

[lee_uk in reply to wantokporo]

I think it only comes in 75mg tablets

[wantokporo in reply to lee_uk]

In the US it comes in 25mg. You might double check.

[lee_uk in reply to wantokporo]

Thanks, I will check

[Hages in reply to lee_uk]

I stated. On 50mg now on 75mg whist tapering off pramipexole!!

[Quiltingmum in reply to lee_uk]

It does come in 25mg, 50mg, 100 mg,200mg tablets and maybe more.

I have reduced from 250mg, down to 200mg as the higher dose was not working so well. I am now trying to reduce that down to 175mg but with varying results. I now sometimes sleep 7 hours but more often my legs start and am up at least once a night, only getting 4-5hrs at the most. It gradually wears me down, but I don’t know where else to go. I have tried the dopamine agonists and Tramadol which all caused augmentation. My GP said I could have the Pregabalin which at first worked well, it was like a miracle to sleep every night. That was about 18 months ago, but it’s all gone haywire.

I figure maybe the Pregabalin is augmenting as I do now sometimes get symptoms in the evening as well as in the night, which is why I am trying to reduce the dose. That and the weight gain, which is a horrible side effect!

Good luck.

[Unhappygirl in reply to Quiltingmum]

Didn't know that Pregabalin could course augmentation

[wantokporo in reply to Unhappygirl]

"They" say it doesn't augment.

[Joolsg in reply to lee_uk]

In the UK it comes in 25,50, 75 & 100mg doses. You can ask your GP to change the prescription ( or have a chat with the pharmacist).

[lee_uk]

Doctors have prescribed 225mg despite me asking for 200mg(will try and change this when I pick them up). They have issued it as 3 x 75mg to be taken throughout the day. Is this correct? I was just taking them 2hrs before bedtime.