The only thing which relieved my R L S was dilaudid . This worked for many years. Last summer I had a cardiac arrest from which time I have been vetoed from this medication.Currently my treatment has been very unsuccessful to say the least.For a year now I have had little sleep and a great deal of acute discomfort.None of the regime is affording much in the way of help for long. Tha tramadol only lasts a few hours then it all starts again.the nuepro caused excessive oedema and mirapex a 24lb weight gain. All in all I am not a happy camper. I don,t know if this information is helpful to anyone.