several people on here have had the same experience as me. I was on an anti depressant & was then switched to Mirtazapine, it seems to be the chosen drug to replace Citalopram. The original dose was 50mg & I went Manic. It was lowered to 30mg. That didn't work & now I'm on 45mg with Epillim 500 chrono. I'm stable, but still feel slightly down. At first I thought that the meds were causing my RLS but it does not. At this time I get it every night but there have been periods when I don't get it for weeks! It is chronic and even if I get to sleep I get no rest. Someone said eat a Banana, believe it or not sometimes it works. I believe it is a psychological problem as it only occurs when laying in bed waiting to drift off and in the back of your mind you are waiting for it to start, then of course it does. I would love to hear from anyone who has overcome this problem.