This 2006 article talks about augmentation and tolerance. It goes on to state that augmentation was rearing its ugly head in 1996 and was very clear to doctors in the field of RLS exactly what was happening to their patients on the dopamine agonists. The leader(s) in the RLS field, who ignored this inconvenient fact, and continued to prescribe away, at ever higher doses, over the past decade or TWO, allowed drug companies (that produced Mirapex and the like) to reap billions of dollars in profit that they never would have otherwise. I'm not a conspiracy theorist, but it seems that this whole augmentation issue really didn't come to the forefront until the drug companies got other drugs for RLS approved by the FDA. Coincidence?
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