Pain "main switch"

NIPS-led researchers measured the heightened pain response when mice with a leg nerve injury were poked on the underside of a hind paw with a fine filament. Simultaneous live imaging of calcium ions in the brain's S1 cortex showed that certain signaling pathways were activated in astrocytes, a type of cell that helps neurons. Certain signaling pathways in S1 astrocytes were activated and triggered S1 cortex rewiring, contributing to mechanical hypersensitivity (allodynia). Such astrocyte-mediated changes in the brain may provide new clues for novel therapeutic strategies for treating debilitating mechanical allodynia

4 Replies

  • Something better for the pain would certainly be welcome.

  • Glial cell inflammation appears as though it's gaining greater acceptance amongst researchers in this field.

  • Much improved upon the view taken by NIH Dr Walitt's  "pain and related interoceptive disorders" as "social construction of illness and disease."

  • Hurry up finding pain off switch pleeeaaaaaase