PSP Association
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Meds 01 L-Dopa

Australian and New Zealand Journal of Medicine

Ivan MacG. Donaldson

Volume 3, Issue 4, pages 413–416, August 1973

Summary: Two cases of progressive supranuclear palsy were treated for sever-al months with substantial doses of L-dopa. Both showed no significant response and continued to deteriorate while on this drug. Because of the sites of maximal involvement, and the extensive nature of the disease process, substantial improvement with L-dopa would seem less likely in this condition than in Parkinson's Disease. This is con-firmed by the few previously reported cases treated with this drug. The rate of progression of the disease would suggest that any response obtained would be of short term benefit only.

My comments: This study is based on only two cases. However other studies concur.

They variously found: In PSP cases it helps with the Parkinson's type symptoms at first.

On Parkinson's websites I see that some folk eat Broad Beans daily (same as Fava Beans) because they are very high in dopamines. They find it very helpful. But no more helpful than taking L-dopa in medication.

Funnily enough Broad Bean Flour is a great dough improver in bread making. The French have used it for hundreds of years at a rate of 2%. We have been using it for two years like that in our daily bake.

I am sure this isn't the last word on L-Dopa

5 Replies

Very interesting! Is there any reference to CBD? Seems an awful long time ago when that research was done. Very little seems to have filtered thru to GPs today, or general hospital staff dealing with Parkinson's type cases. They just carried on treating my man without checking progress/lack of!


I know a little less about CBD. However if it is about neurofibrular tangles and Tau protein plaque, then it has that in common with Alzheimer's and PSP. I'm fairly sure that is the case.

What I found interesting is that with Parkinson's disease and anaesthetics L-Dopa is administered before, during and after the operation to prevent the anaesthetic worsening the condition.

Yes, it seems to have taken ages for the information to filter through. I was rather shocked to see the date on Huw Morris's paper 1999. I suspect that in the U.K the PSP Association has had an impact, because more and more when I mention PSP to medical people they at least say they have heard of it.

"They just carried on treating my man without checking progress/lack of! " - Depressing isn't it, just as well he has a carer who can bark when needed. ;)


Sadly, there was never enough time to take it all in. Am thinking back now to when he had anesthetic and whether that started things off - 2003 or so! Kidney stones.


"Never enough time" Yes, life is so full on these days.

Reading about anaesthetics I shall try to minimise my needs too. Having said that a number of papers, though showing concern, state that if you need an anaesthetic then what alternative do you to have, but have it.

I guess I have been reading into all of this so that I know where and when to ask questions of the medics concerned.

Smiley waives and Hugs to both of you.. we soldier on.


hypnosis! Now this may not be good for the neuro-degenerative patient, but my mother-in-law used this when giving birth! Thank goodness, Bruce was a 10 lb-er (22kg)!



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