Eosinophils, Lymphocytes & ELR number crunching

[Justfor_]

I crunched the data of 15 PSA and WBC pairs. Out of the total, 6 show a PSA increase, the remaining 9 a stable state. I calculated the mean (absolute) values for the two subgroups. Neutrophyls, Lymphocytes, Monocytes and Basophils show approx 5% diff. between the two subgroups. The only one standing out with 28% is Eosinophils. Combined with an inverse 5% of Lymphocytes, the ELR (Eosinophils to Lymphocytes Ratio) wins the crown with a 35% diff.

Interestingly enough, the opposite than anticipated was found with LNR. 3.16 for the up going vs 3.52 for the stable, a 11% diff. Literature indicates that a lower LNR is better with cut-off points varying between 3-3.5.

A relevant paper, in essence saying that an increase in Eosinophils is a positive marker:

A Transient Increase in Eosinophils Is Associated with Prolonged Survival in Men with Metastatic Castration-Resistant Prostate Cancer Who Receive Sipuleucel-TI

cancerimmunolres.aacrjourna...