TRIMIX PEYRONIE'S ANYONE?

[Fairway]

Urologist says Peryronie's a possible side effect of Timix injections. Anyone experience this?

[baw1955]

Yikes! Got my first injection a few days ago. My dick isn't crooked yet, am a little concerned though. I will ask my URO about the connection bewteen Trimix and Peyronie's.

[Fairway in reply to baw1955]

Possibility slight long as you don't inject same place each time. ... How did it work?

[baw1955 in reply to Fairway]

My wife and I enjoyed long, loving, lustful, liberating sex yesterday. Awesome and so satisfying -- first time since my RRP in Oct 2018. And all enabled by Trimix injection. Can't sing enough praises for the 0.2cc I shot into myself.

[Tall_Allen]

Some men are more prone to forming scar tissue than others. MUSE doesn't cause Peyronie's but it usually isn't as effective.

[tvankirk]

I developed Peyronie's after using Trimix for 9 months. I do not recommend it.

[baw1955 in reply to tvankirk]

Just posted the extremely positive experience we (my wife and I) had with Trimix. Now I will think about continued use and possible consequences based on your outcome. Thanks for sharing.

[tvankirk in reply to baw1955]

When mine occurred it wasn't gradual and I had no warning. When it occurs your penis will become noticeable shorter with a significant hook. When I started getting some natural erectile function back it was too late to undo the damage and my insurance wouldn't pay for treatment. Using Trimix just made a bad ED situation worse and now I'm stuck living with the damage.

[Hidden in reply to tvankirk]

Try using L-Acetyl-Carnitine and L-Arginine. It might help.

[tvankirk in reply to Hidden]

Thanks for the suggestion! I'm taking a GNC mens health supplement that contains L-Arginine and just purchased the L-Acetyl-Carnitine on your recommendation. I'll try anything at this point.

[Hidden in reply to tvankirk]

Here's another recommendation I just came across: (lugol's solution of iodine)

newsmax.com/t/health/articl...

I have no personal experience with this particular treatment but sounds like it might be worth a try.

[Vitruviusman]

NOT ONLY PEYRONIE, BUT ALSO HEMOTOMA'S AND PENIAL SCAR TISSUE.. NOT FUN...

[cpcohen]

I've always wondered:

How many cases of "Peyronie's caused by Tri-mix" are actually cases of Peyronie's that have been caused by a long period of "no erections",

. . . and only become visible (and maybe get worse) after injections are started ?

It's a question worth asking a urologist . . . As are the questions:

. . . "OK -- I know it's a possible side effect. How often does it happen?"

and:

. . . "What do you propose that I use, if not injections, since oral drugs and a VED don't work for me?"

I've been using 31-gauge needles (that's finer than most docs recommend) for ten years, with bi-mix (for 9 years) and tri-mix (for about 1 year), and haven't had a problem. That's injecting, rotating among 4 spots, once or twice weekly.

I was looking at a paper, recently, that reported outcomes of injection use. Peyronie's was one of them, and I _vaguely_ remember it happening at about a 5% rate -- one out of twenty men. I'll look it up, if I can find it.

. Charles

[cpcohen]

See the response from "FCoffey", here:

healthunlocked.com/prostate...

. Charles

PS -- the paper referenced in the lead post, is the one that has data on the incidence of Peyronie's -- I'll find it for the parallel thread.

[407ca]

I have been using trimix for 6 months. I was told by my doctor to alternate sides to lessen the chance of any curvature issues. So far all is well.

[FCoffey]

It's a question of cause and effect. Peyronie's disease isn't very rare, about 10% of men are afflicted, mostly later in life.

onlinelibrary.wiley.com/doi...

Table 2 in the linked publication shows that development of Peyronie's disease was given as a reason for discontinuing Trimix. That's hardly surprising, Peyronie's disease can make intercourse difficult, uncomfortable, or impossible. If so, stopping an invasive ED treatment makes a lot of sense. There's no evidence that Trimix is the cause.

The paper states that

While there is no direct link between the use of ICI and the development of tunical plaque, there is now a link established between RP and the development of Peyronie's Disease.

So multiple studies have shown no direct link between Trimix and PD, but RP HAS been implicated in increased risk of PD.

So the sequence looks like this, in a PCa patient

1) RP

2) ED

3) Trimix

4) development of PD

The patient blames Trimix, but the real cause is RP.

Nothing is perfectly safe. Every man must make his own decision about the risks and rewards of every one of our treatment decisions.