18F-DCFPyL PET/CT Scan at NIH

[dac500]

I have appointments for MRI and 18F-DCFPyL PET/CT at NIH (Clinical study) on October 22 and October 23. I also have an appointment for Axumin PT/CT scan at Penn Medicine. My question is whatever is the outcome of the 18F-DCFPyL PET/CT scan will Axumin scan make any sense?

[Tall_Allen]

The DCFPyL PET scan is far more sensitive than the Axumin PET scan.

pcnrv.blogspot.com/2016/12/...

UCLA just completed a comparative trial of Ga-68-PSMA-11 vs Axumin (fluciclovine), expanding a small trial reported here:

jnm.snmjournals.org/content...

As you can see, there were no mets discovered with Axumin that weren't discovered with the PSMA-based scan, and DCFPyL is even more sensitive than Ga-68-PSMA-11.

I think you can safely cancel the Axumin scan.

[dac500 in reply to Tall_Allen]

My Axumin scan is on November 5. I will cancel it as soon as I have the 18F-DCFPyL PET/CT scan. Thank you very much for your information a few months ago, which led me to apply for the clinical trial.

[Bill2544 in reply to dac500]

How did the 18F-DCFPyL PET/CT scan go? Do you know if they are still enrolling and what are the criteria? I've had both an Auximin scan (non-informative) and a Ga-68-PSMA scan (phase 1 trial -- Dr. will receive results) at Penn. Sounds like the 18F-DCFPyl trial might be next if I'm eligible and can get in. I'd appreciate any feedback.

[dac500 in reply to Bill2544]

The NIH 18F-DCFPyL PET/CT scan study makes more sense when MRI, CT, and Bone scans are all negative, but the PSA is rising after RP or RT. If you are on ADT, you are disqualified. If Ga-68-PSMA is positive, then there may be no purpose to have the 18F-DCFPyL PET/CT scan. You need to contact NIH to get details.

[Bill2544 in reply to dac500]

Understood. Thanks!

[cesanon in reply to Tall_Allen]

There is a related question.

When does it make sense to do a scan, when you already know your cancer is metastatsising.

[Tall_Allen in reply to cesanon]

That's discussed in this article under "PET scan uses":

pcnrv.blogspot.com/2016/12/...

[cesanon in reply to Tall_Allen]

Nice article