I'm posting about this and including a link to see if you can read it without registering for Academia - which is an enormous educational facility to download PDFs of published papers free of charge. I registered a couple of months ago and they have sent me loads of publications related to PMR. It is up to authors to upload their publications so is not exhaustive and they are pre-publication versions so there may be minor changes in the published papers. If you do have to register they do plug their all-singing all-dancing version that you have to pay for! Easy to ignore though. They even sent me a list of all MY publications that appear there!
However - that said, this article is very comprehensive and not very out of date, covering a lot of papers and aspects that are sometimes not included. Definitely worth a read. The Spanish groups are very good which is always a bit surprising with the northern preponderance of PMR but it is the same in Italy.
Thanks for the link , it's one of the medical sites I hadn't signed up for yet.As you say a bit of fiddling about setting it up for the PDF but it looks like they have a good library of papers so it will be worth it.
I do find the words splashed across the page a bit annoying though.
Thanks for the link I was able to register, fear I might go down a rabbit warren and not surface for a week if I start reading today!
However a Japanese study 2024 caught my eye were an older age group , actually all women between 70 and 80 were initially treated with higher doses of Ibuprofen. To spare them taking steroids.
It would be interesting to see if the patients were ever followed up?
Is it 2024? Sometimes the actual publication date is different. But it isn't recommended in the international recommendations - it used to be - and the longterm risks in elderly patients for cardiac and renal function are considerable. Plus most people on here would tell you ibuprofen doesn't touch the sides! I have a friend who had a gastric bleed after 3 standard doses of ibuprofen as instructed by her GP for PMR. Can never take it again.
Yes , that's a big issue most people are dissuaded from using ibuprofen these days.I know since I began having gastric and gall bladder issues years before all the other stuff turned up the Consultants warned me off Ibuprofen for life.
I'd never had a problem with it and did find it useful but they still gave it an absolute ban.
I've never taken ibuprofen, owing to family history, and my own history of two stomach bleeds, in those cases probably from 1) aspirin (which I still take, but more carefully) and 2) naproxen (which I have never taken again) and just remembered 3) minor episode from topical diclofenac (the first two occasions decades apart both caused me to collapse and I was hospitalised for the first one and given 4 units of blood, thankfully preHIV). Nah, I don't think ibuprofen would ever have been a good idea for me as it actually comes with a warning about increased risk of stroke, unlike aspirin.
Regarding Ibuprofen, I once bought a box of these tablets back in the 80's, hoping they'd cure a bad headache I was suffering from. As soon as the tablet hit my stomach it caused an excruciating cramp that lasted a long time. It didn't even touch the headache either, so just the one tablet meant I had a throbbing head and a fully cramped stomach, not the outcome I was hoping for.
Needless to say I threw the rest of the box away and have never taken one since. It's annoying though, as a nurse friend of mine told me she could eat them like sweets, with no ill-effects whatsoever. Grrrrr!!
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Kevzara (sarilumab) is approved in the UK for the treatment of polymyalgia rheumatica (PMR): 
A-Z of Life in Remission with Polymyalgia Rheumatica
The Lighter Side: Product / Consumer Review - POLYMYALGIA RHEUMATICA (Product Code PMR 001). My Scores out of ‘5’. But You Decide…? :-)
Help in describing PMR to family. 
