CRP elevated too high - why?

[Dragonflys]

hi. My blood labs show my CRP was 9.4 in June. I had pain and increased my prednisone to 3mg. My pain stopped snd Ive been feeling great. Now my Labs todsu in August show a further increase in CRP to 19. My ESR is normal at 12. I dont understand why as Im feeling good and tnought my CRP should be down. Im so devestated and depressed by this. Its been 5 years now and I never have had this happen. Can anyone give me some guidance and advice?

Thank you in advance.

[123-go]

Sometimes anxiety itself will cause a rise in CRP, or an infection, lack of exercise, poor diet, eg. foods high in carbohydrates, not drinking enough water. If my CRP rose without explanation I would speak to my doctor/rheumatologist for reassurance.

[DorsetLady PMRGCAuk volunteer]

As 123-go has said anxiety , amongst many other things may cause an increase in inflammation markers.

Mine have been raised a couple of times once when my late husband was very ill [I did still have GCA at that time but no flare whatsoever] - and again a few years later [GCA in remission ] but following a couple of replacement surgeries, 6 months apart.

But would also say, if CRP is raised but ESR isn’t it could just be a glitch, an issue at the laboratory or similar. So get it retested and see what that is. A one-off out of sync result should be reviewed.

[Dragonflys in reply to DorsetLady]

thanks for your advice - will def retest in a fee weeks and see.

[PMRpro Ambassador]

Other things can raise it besides PMR. What does your doctor say/think?

[Dragonflys in reply to PMRpro]

I havent spoken to my doctor yet and my next appt with rheumy is in October. Was wondering if having fallen and having a very bad bruise on my hip could have done it? As well had a mild case of food poisoning several days ago. Wonder if that could make it go up?

[PMRpro Ambassador in reply to Dragonflys]

Both could, especially if the muscles were badly bruised in the fall or even others wrenched as CRP is also a muscle enzyme. CRP is seen to be highest about Day3 after a poisoning event and then falls again - does that fit?

[Dragonflys in reply to PMRpro]

I think this is likely what happened. Im going to repeat my bloodwork in a few weeks and see.

It was just rather depressing seeing the lab work result. Ive been also dealing with a lot as my adult daughter who struggkes eith anorexia is discharged from hospital and still struggling. I am a grsndmother and helped to raise my grandchild , and well life has been not easy. However there has been a lot of good too so Im not complaining but stress probably is a factor in why I ever became sick and maybe even now - who knows? I just go day to day. But thank you for the help. Its hard when you feel alone with this disease.

Thank you!

[PMRpro Ambassador in reply to Dragonflys]

Stress will raise CRP and ESR - and you are stressed.

[piglette]

I have a very high CRP all the time. The highest was 412 and the lowest 29. The doctors have decided it is just me after various tests.

[Dragonflys in reply to piglette]

That is very interesting. Something to remember.

[piglette in reply to Dragonflys]

My only worry is the doctors may be wrong!!

[Dragonflys in reply to piglette]

Yes I know. it is not easy this disease - it always has twists and turns and ups and downs. Its a wild ride I never wanted! My best to you that all is well with you!