Stiffness/sore muscles

[LemonZest11]

I have been off prednisolone for 60 weeks now, and on TCX for 4 years, but on 4 weekly jabs for 40 weeks. That fourth week before the jab I usually experience a bit of fatigue, headache and sore muscles, which seem to go once I have that jab. This is that 4th week and I have been taking ibuprofen 2 x 200mgs in the morning and it works!! I haven’t needed to take any more, although by bed time I’m feeling the muscles again. So the last two nights I took the ibuprofen quite late, before bed, and woke with no muscle stiffness. I’m wondering, gurus, could this be something else to do with IL6, which can be alleviated by ibuprofen? I have been physical, in the garden etc., but I’m always like that and I only feel it in the week before the TCZ jab, which restores me once again. 🤷‍♀️

[PMRpro Ambassador]

Now you're asking!!!!!

[PMRpro Ambassador in reply to PMRpro]

Try this for size to start with

pubmed.ncbi.nlm.nih.gov/338....

[LemonZest11 in reply to PMRpro]

I KNEW you’d know. So it looks like good news. So TCZ is keeping what under control? PMR? LVV? Or is it fulfilling the role of placating my older muscles?

[LemonZest11 in reply to PMRpro]

What I’m asking is, does IL6 play a role in “normal” muscle soreness in older people after exercise? Not huge exercise, but walking, pruning, lifting logs, you know, keeping yourself busy? And does TCZ help with this? If so, we should all be on it!!!

[PMRpro Ambassador in reply to LemonZest11]

It sounds like it from that paper doesn't it? Must read it more closely. Bit pricey compared with ibuprofen though

But you are doing so well!

[LemonZest11 in reply to PMRpro]

It does. I will see what info I can find, but yes, a pricey tonic. My point was more about taking a risk and seeing if 2 x 200mg ibuprofen each day might replace the job of TCZ, that's if the ugly sisters have gone into remission, but I'm always wary. We're heading to Greece in 3 weeks so I'll leave experimentation till I return. I'll be seeing my lovely Rheumy's replacement the week we get back so perhaps I'll run it by her. Food for thought. You know how cautious I am. You are also doing well!!

[PMRpro Ambassador in reply to LemonZest11]

How is the new rheumy or will that be the first time? Hope the weather in greece improves by the time you get there - the Med has been a bit disgusting recently!

[LemonZest11 in reply to PMRpro]

It will be the first time. She's much younger but I have more confidence in myself and in my previous Rheumatologist's notes, which probably read, "this one is trouble!". Disgusting weather? Hey, I live in the land Downunder!! Droughts and flooding rains!! 💪

[PMRpro Ambassador in reply to LemonZest11]

Sounds like here ,,,

[PMRpro Ambassador in reply to PMRpro]

Except there was snow in sight overnight!

[LemonZest11 in reply to PMRpro]

Four seasons in one day??? East coast of Australia, we're I'm from. We live on the west coast ... hottest summer on record. In the last 3 days, we're all complaining about the cold. Mind you, it was 24C today 🥶 😂

[PMRpro Ambassador in reply to LemonZest11]

Monday last week I sat on the balcony because it was sunny and about 18C I think. The Sunday had been 26C. Since then it hasn't made it into double figures and next to no sun to take the edge off. There are snowflakes all over the forecast for today. Next Monday is supposed to be mid-20s again after Sunday just manages to be average for the time of year so the rest of the week here is still cool. Even Lake Garda is barely into double figures today.

[LemonZest11 in reply to PMRpro]

Sounds like Oz, but at least you're heading into warmer times. Snowflakes sound lovely.

[PMRpro Ambassador in reply to LemonZest11]

Not at the end of April they aren't!!!!!

[LemonZest11 in reply to PMRpro]

Haha 🥶 ❄️