shortness of breath subsequent to zoledronic acid infusion

[Angel_doll]

Because of GI problems, bisphosphonate tablets are not an option for me, so I have gone down the infusion path. I had my first infusion on December 28th, and experienced about three days of bad muscle pain, which then resolved itself. It was a couple of weeks later that I noticed that my ankles were a little puffy, and I was getting short of breath more quickly when I went on my daily walk of ~3 kilometres.

I have consulted my GP, had a CT scan this morning, and have been referred to the local Rapid Access Chest Pain Clinic, although I do not yet have an appointment. I am not experiencing chest pain, but sometimes a little discomfort and tenderness along with the shortness of breath. The only cardiac diagnosis I have ever been given is occasional ectopics. My GP wants my heart checked out as apparently angina can present as shortness of breath without pain. He has prescribed me a GTN spray.

I am currently tapering from 6mg to 5.5mg pred, over five weeks. My rheumatologist put me on a tapering schedule of .5mg every 4 weeks, but I am happier with the extra week.

As shortness of breath is listed as a bisphosphonate side effect, I wondered if anyone else who has had the infusion has experienced anything similar to this?

[Missus835]

Hi Angel. I had a ZA infusion in October 2023. So far, nothing that would present itself as a side effect. I do have a slightly tender breastbone and bottom of esophagus, but also have pulling back muscles from fractured vertebrae. So it could be the muscle factor. It's difficult to tell as the back muscle pain trumps everything else. I could not take the tablets either due to GI issues. Osteoporosis Specialist did tell me that it takes the infusion 5 or 6 months to have the bone-strengthening effect kick in. She also said the infusion was a good choice for me. I hope your symptoms resolve soon.