Hi all, would like some advice please. I've posted a few times before regarding my suspected PMR (even though I'm 45 yrs old). Last week I was given the coated Pred to take (after having non coated for a few weeks). I'm on 30mg per day. From what I understand the coated Pred takes longer to enter the bloodstream so I have been experimenting a little on when its best to take it. The night before last I took 20mg at 9pm as I figured that I normally wake in pain about 2-3am. This seemed to work very well, I woke up at 3am as I had a slight night sweat but there was no pain in my legs (just stiffness). I took the remaining Pred at 3.15am and went back to sleep and woke again at 7am feeling a little stiff but generally ok. As the dosage and time seemed to work quite well I tried the same again last night. However, this time round I coulf not get to sleep until 2am and was in pain up to that point. I woke up again in pain at 4am and took the remaining 10mg Pred and managed to sleep until 6am. I don't understand how the two nights can differ so much, it's as though the Pred I took at 9pm last night had zero effect. Does anybody have any thoughts on this? Also I'd be interested to hear what to recommend for pain relief. I've been taking paracetamol and Oromorph but it's not always that effective. Thanks for your comments.