Thoughts please on prednisalone dosing

[siskin]

I ave RA and PMR and have to go up from 5mg to 15mg. pred.

I would appreciate thoughts on whether to take all dose morning, all evening or divide the dose in some way.

Thanks in advance.

[Celtic PMRGCAuk volunteer]

siskin, it has long been recommended that the best time to take Prednisolone is the whole dose with breakfast as early in the morning as possible.  Having said that, there are a few people on the various PMR/GCA forums who have found that they fare better by splitting their dose two-thirds in the morning and one-third in the evening.  It really all depends on how long the effects last in your body - anything between 12 and 36 hours is possible.  Like most people, I took my whole dose first thing in the morning with a breakfast which contained a small pot of 'live' yoghurt for stomach protection (I was unable to tolerate the usual stomach protection meds often prescribed alongside steroids).  

[leeman49]

Doctor prescript me 15mg and once daily in the morning. It seems a good ideal as you don't have to worry about extra food before Pred. I took it with breakfast. If you are not sure you can checked with your doctor. 

[PMRpro Ambassador]

The best way to take pred is - as Celtic has said - the way that works best for you.

If taking it once in the morning works well that is better with regard to side effects than splitting the dose - your body has long between doses with no pred in the body. On the other hand - if the pain-relief effect doesn't last 24 hours then splitting may be better for that. Everyone is different but most people manage with one single dose in the morning.