it takes 4 or more hours to get total relief. If I take 3 ibuprofens an hour after taking my 3 mg, the pain is gone in 20 minutes totally. My rumy says it is okay to take the ibuprofens. I don't need it every day but I think I could come off the methypred and just take ibuprofen. Has anyone experienced this and tried ibuprofen? If I take 4 mg it works too but I am trying to get off the meds.