An injection amount divided by 2 and administered 10 minutes apart is more effective for my body.
New discovery: An injection amount... - Pernicious Anaemi...
New discovery
Hi Wiz
Interesting!
What dose and which B12?
What criteria did you use to evaluate effectiveness?
TIA
🤗🤗🤗
When ever I start a new trial I create what I term a hole in time. A period of time where I have lots I can do but as little as possible that needs doing. Of course life always gets in the way.
I observe the effects for the first day or so but do not consider it good information as I have found that I most often experience an uptick followed by a sight downturn then things level out. At this time I usually can tell within 7 to 10 days the effect of the change.
In the past I have attributed the uptick to my body getting more what it needs and then the downturn to my body adjusting to having more what it needs. I am not sure what I was experiencing as relief from accomplishing the design and then executing it after doing that work. I am not sure the downturn was not from still under supplementing.
There are certain things I can depend on if making a change that is positive. My memory works differently and I can process past traumas and experiences. That is hard work and disruptive and I expect 'uses up' my B12 while I am doing that work.
I also experience what some might determine to be anxiety which I see as my emotional pathways opening and the anxiety was always there but manifested differently. I process the trauma and it is in my past.
I can also count on a disruption of my digestive system which I attribute to my digestive system which is controlled by my neurological system to be healing. It used to be severe but now is not. I do not alter my diet as part of my self treatment. I did through out my life determine how to mitigate my B12 deficiency with diet and thought I knew what I was doing when in fact I was doing a work around without knowing it.
I can also expect to need more sleep and rest as my body adjusts to improved supplementation.
I do go though the feeling that I am insane and this is all in my head.
I also use the concept of plateauing. Now I use the concept of my rate of improvement has leveled off.
I consider it a flaw of the EOD method that assumes that EOD 1mg is all that could possibly have an effect when in fact what happens is symptoms stop improving due to less B12 than can be a benefit. That it is really a plateau. This is born out by anyone who injects more than 1 mg EOD.
It was important when I decided that just because I am feeling less worse that is not all that is possible for me and it is just a matter of waiting.
My main subjective evaluation is if I sleep and dream well. My second is if I need to recover from life and not just rest and sleep. I have not yet got to the point where it is reasonable to accept that my life will be limited by my bodies need for suplimentation other than the effort needed to make it happen.
With this last discovery it was obvious that the effect was positive. I slept for three hours in the morning after starting the trial and felt better.
There is the aspect that with my work I have experienced substantial improvement so I cannot recognize when it is happening.
Thank you for asking it was good for me to write it all down rather than just having it in my head.
Hey Wwwdot AKA Triple W-ya I did more work on the homework you assigned with regards to evaluation. 🙂
I forgot to mention in my reply that I use the term "acuity index" It is not numerical and very subjective. I use it part to stay away from negativity and not get carried away with well this is a lot better than before. It is ambiguous on and with purpose.
I use it when starting a new trial to as best I can identify the slight downturn which I attribute to my body needing energy to heal. I might notice that I am not quite on and it is harder for my brain to work. I accept it as from the improved supplementation and do not try and force thing which is my nature. Nor do I blame myself for needing to rest and sleep to heal. As best I can.
I used to use fading much in the same way. I started fading about a year ago at 11:00 on a good day and then would sleep. I kept improving my supplementation and then it became I would not fade I would just get tired at the end of the day.
I have a solar powered Fairy light given to me by someone I love and choose to put off starting a D3, K2 magnesium protocol that someone was nice enough to share on this forum when that Fairy Light did not have enough power to be lit through the night. So I am building up the courage to start that and see how that goes. It is easier following someone else that has done the design work to start. I do not have a method to evaluate so it will be a observe and guess method at least to start. Made more difficult as sun energy is not going to be as available. Oh bother.
Hi WizardWhat made you think of doing it that way.
Have been wondering for a while about keeping the frequency but only injecting half the amount. Easy for me at present as I prepare 1 for myself & 1 for my mum at the same time, so can split 1 ampoule. Especially as we are using the 1.5mcg per ml so we would still get .75ncg.
Never thought of doing two though.
I do this. My husband and I each inject 500 mcg. from one vial. (Different syringes) We increased the frequency of the injections to get what we need.
"What made you think of doing it that way?" 4 years of exploration, discovery and hard work. Much of the work was evaluating what others thought to be true and was not based on rational thought and incorrect.
My discovery is the 10 min between injections keeping the amount the same not splitting by hours. I know nothing about that effect.
This sure makes sense to me. I have read that a very small amount of a dose one ingests is absorbed. No one can say for sure per individual but if you inject, ingest more, the amount absorbed does not increase exponentially. That said, I am am surprised only ten minutes makes a difference.
A month ago I experimented with splitting a 1mg ampoule into 2 syringes, then injecting with one syringe each day. I tried it to six days but my cognitive symptoms began to show. I went back to EOD 1mg. My take away was, whilst only a very small percentage may be absorbed, the unknown is how much B12 (hydroxocobalamin in my case) needs to flood the system for the optimal portion of B12 is absorbed (in relation to external management— injections, as opposed to the bodies natural cycle).
Thank you for sharing your discovery for your body.
As for your explanation as the cause that is possible but not proved. That is typical with the study of the effectiveness of treatment. I no longer spend effort in what might be other than in design of my treatment. Results are my measure.
Currently I am focused on energy production at the cellular level for the most part as my symptoms of B12 deficiency have resolved.
Not a description but rather a hypothesis. I, like you, would rather listen to my body (within reason) and evaluate what I’m experiencing in light of what I’ve learnt dealing with B12D.
I understand.
I only use hypothesis when designing a trial. Once the trial starts then I evaluate not based on the validity of my hypothesis rather on the actual results.
When designing a trial I often ask if my hypothesis correct would it be known and the answer is always not with the restrictions of what is thought to be true.
I do not use the hunt and peck aka find what works method.
I did not discover paint, brush or canvas. This does not mean I can not create a painting that is meaningful to me. Nor have I ever done a painting and needed someone to tell me what it means to me. It is meaningful when someone tell me what my painting means to them. I do not care if they think it is beautiful or not.
Thank you all for your reply's! Let me know if you have any information on my discovery.
Have you abandoned 3 Shots/day while you trial this new process?
No I keep everything the same as I am not about only finding what might work.
By keeping everything the same as best I can I am able to tell what the effect of the change is.
I no longer have to wait a month for results. I knew in days this change was positive and it has now been 10 days and that trial is complete and I have designed the next one based on the information from the last 4 years. I will integrate the knowledge gained into my self treatment and future designs.
This trial was from my hypothesis of a year ago +- that the efficacy of B12 injections with regards to frequency is unknown and what is thought to be true is not. It was part of my process to understand how the current understanding of B12 was incorrect and the reason which is B12 is treated not as a supplement rather a medication. Simple explanation.
Splitting a dose by 10 minutes and experiencing a higher efficacy does not at all meet the current understanding of how the body utilizes B12, it refutes it. This does not mean I can know how the body utilizes B12 only that those that claim to know are incorrect.
Some cells in my body can only utilize B12 for the first 10 minutes after an injection. I leave it to others to apply the MUSS principle. Make Up Stupid Shite.
Dr. Davis Morris claims that B12 enters the body and has a half life of 10 min at best then it enters the liver to be released into the lower intestine where if you experience PA can not be utilized. He is using the MUSS principle. There are a multitude of possibilities and to limit the concept of shorter time between injections principle only to those who at one time tested positive for antibodies is bullshite.
I have also established that the same amount of B12 in less saline is more effective. Concentration. That it would be different is simple chemistry and refutes current understanding.
That is my next trial. I am getting my head right to be able to evaluate the results of that trial and setting up my life with as few variables as possible. I will again change the concentration and evaluate the results. Not only if it works.
The trial after that will be magnesium, D3 and K2. With that trial I will follow the work of others that have done work on efficacy as a place to start.
I no longer share my process here for the most part. Converting my notes which are cryptic and only readable by me to readable prose is laborious and has no effect on how others self treat for the most part. My notes are written much as I write notes as a environmental scientist. A competent environmental scientist could understand my cripitic notes if the notes were in our field. They could not understand my notes for B12 as they do not use the nomenclature of B12.
I do not know the biochemistry of this discovery and no one else does either. [....] I can not predict anyone elses results. Logic does dictate the only way to know is to try. I do not instruct or advise.
Note - minor edit by admin
sweet. I just couldn't prick myself that often. Doh.
Tell me about it. It is hard to design and execute a trial when I am not sure I want it to work and have to maintain it. I trick myself by saying it is just information and I will deal with how to apply that information later.
It is not totally a trick as sometimes I can come up with another idea to get the same results.
In a better world experts would design compounded injections based on the persons genetic testing and monitor the results and then design a more effective compound. Then address diet. Current method is to diagnosis incorrectly then one size fits all. Often trying to test a serious illness with diet. Nothing new in that method. I did not cause this illness by becoming a vegetarian. I was a vegetarian in my 20's I could not keep up and vegetarians could not keep up with me if I ate fish and a occasional prime rib. Maybe I will celebrate my success with some prime rib. Maybe with Rib Eye. Good Gawd! I am designing a celebratory meal.
I did find some syringes that were 31 Gauge and only 5/16 long which I find easier to use. Thing is they are only .3ml.
While writing I came to understand that I avoid any trials with IM based on my experience years ago when they were extremely painful. That likely is no longer true as my body is not the same.
I definitely appreciate the trial info! Keep us posted
The trial integrating the new discovery lead to healing. The results were eventually more energy, fading less at the end of the day, fading not starting until later in the day.
I also after a while came to understand that recovery from pushing was improved. I did a trial of working in the yard all day and then at the end of the day going past when I faded. This resulted in my feet aching. Remnants of the Peripheral Neuropathy. A few weeks ago this would resulted in minor pain at night and then my acuity index being low the next day. I took a warm shower and slept well and there were no negative effects that next day.
It felt like the pushing was healing. I came to understand I have been seeing being able to do more as the result of my improved self treating/healing myself which was accurate.
I am pretty excited that I may be on the cusp of being able to push to heal in a more profound way.
I discovered a while ago that the same amount per day of B12 at a higher consideration is more effective so I am doing a trial of increased concentration along with the spacing.
It is good for my head to be using my discoveries in combination. It is what is known as an elegant trial. One where the amounts stay the same and the frequency and or concentration is changed. An elegant trial may or may not lead to a solution or may be negative.
It is not my ego. Mick Jagger has low self esteem compared to me. 🙂
I am dragging my feet on doing my next design. The improvement is a big change to my day to day life and I am experiencing eustress as well as having to process my trauma in a way that was not possible before my emotional pathways were more open. It is also hard to trust my cognitive thought being easier. Results are the same, just takes less effort. And yes I do sometimes go back to the comfort of seeing things the way I did before.
Hey if it was easy anyone could do it. Well not doctors they do not have what it takes.
I find it helpful to see doctors as being trained for 10 years on how to medicate, order test and give surgeons work. Health they suck at and may over all be detrimental.
Emergency treatment is what the medical field excels at and I separate that from GP's. Keep you alive and then turn you over to less gifted doctors who also have a more difficult but less exciting task.