Gastric Secretion and Acid Regulation

[Technoid]

Mentions the Parietal Cells, Intrinsic Factor and B12.

m.youtube.com/watch?v=3pYzD...(Not working as expected?)

[Wwwdot]

Thank you Technoid

Just watched it.

I wish my ears worked as quickly as his mouth!

I will listen several times.

🤗🤗🤗

[lifegems]

Hi, thanks for this info . It seems to imply that if we have a problem with intrinsic factor we also can not absorb protein ? Have I got that right ?

[Technoid in reply to lifegems]

That is a good question and is a reasonable implication from the material presented!

By good luck I came across an answer to this in my copy of Costanzo's "Physiology", a standard physiology text.

"Interestingly, Pepsin is not essential for normal protein digestion. In persons whose stomach has been removed or persons who do not secrete gastrin H+ (and cannot activate pepsinogen to pepsin), protein digestion and absorption are normal. These examples demonstrate that pancreatic and brush-border proteases alone can adequately digest protein."

An earlier section states that "Intrinsic factor is the only essential secretion of the stomach."

[lifegems in reply to Technoid]

So if intrinsic factor is essential yet those of us with PA don’t have the correct working IF what else can we do other than supplement B12 with injections?

I find this all so confusing. I self inject approx every 2 weeks but I’m still very tired and have limited energy. I would love a solution.

[EllaNore in reply to lifegems]

Hi lifegems, perhaps you could try more frequent injections. I do about everyday. Sometimes I forget. Which is good, I think. Because my body didn't remind me. Perhaps once a week or every few days would be good for you. But also other underlying conditions can go on and everything gets blamed on B12 when it's really not. However, with one autoimmune condition there are usually several. I really feel doctors should look at hypothyroidism lupus and other blood disorders like thick blood Etc. I have thick blood. I know other people on here do as well. That can really make you tired and b12 isn't going to do a darn thing about it. At least it isn't for me so far. Not directly. So there are other things that you should have checked to rule other stuff out.

[lifegems in reply to EllaNore]

Thanks . Never heard of thick blood . How do they test for that ?

[EllaNore in reply to lifegems]

For me I kept having high mpv/mch and other blood tests that were out of whack. They kept ignoring them for a long time and I kept saying why is my MPV so high they said it's high but it's not that high and then I showed them pictures of me how my face swells how my body swells, rashes all over my body. I told them all about my other symptoms and finally after 3 years of telling them, my rheumatologist ran a BETA-2 GLYCOPROTEIN ANTIBODIES test. This is what it looks like. The one that is 55.7 is too high and tells me I have clotting factors in my blood and that it is too thick. It makes me extremely breathless extremely fatigued terrible headaches. And it's also affecting my bladder. The thick blood can make your kidneys and your liver have to work extra hard because they're not getting the oxygen they need. It also affects your lungs very much. If you have fatigue that is just not getting better and your heart is good and everything else is good they really need to check your blood. It only took me 3 years to convince them there was something wrong with my blood other than pernicious anemia. They insist that I'm not anemic yet my MPV is always high which means that I have some kind of megaloblastic anemia. Where your bone marrow makes too large of blood cells or something like that. it's something very close to that but it has to do with your bone marrow making blood cells and them being too many or too large. Now I have to wait three more months to take the test again and find out if my blood is still thick. In the meantime I have to worry about blood clots and a stroke or a heart attack or blowing out my blood vessels. It also causes hypertension. And when I take my blood pressure medicine at night my heart rate goes so low that my watch sends out warnings to me that my heart rate is too low and when I wake up my face is completely swollen. So I'm hoping that when they thin my blood or they find out whatever's causing this it helps with all of this. But I really don't know anymore about it than this and I'm not even sure that all of my information here is exactly correct. So please Google things yourself as well to make sure. Googling the name of the test will give you a bunch of information.

BETA-2 GLYCOPROTEIN ANTIBODIES

[lifegems in reply to EllaNore]

Ok thanks I’ll do some research. Sorry to hear your having such problems

[Technoid in reply to lifegems]

Hi lifegems ,

Indeed, for PA there is nothing to do than take B12 injections at a frequency where it alleviates symptoms. This varies a lot from person to person. Some can get by on very high doses of oral B12 but for many, the only option that works is injections.

As EllaNore suggested you could try more frequent doses, at least once a week I think and see if that feels any better. Some inject as frequently as every other day - this is sufficient to fully saturate every active transporter that carries B12 in your blood.

Be aware of other conditions that may cause tiredness - however I know its probably the most common long-term complaint among those treating PA.

[lifegems in reply to Technoid]

Thanks ! I hate having to SI but maybe need to do so more .. what worries me is that I seem more tired than I did a few years ago and I just hope this is not a slippery slope

[lifegems in reply to Technoid]

Thanks .. I hate SI but maybe I need to try more frequently

[EllaNore in reply to Technoid]

Very interesting and great question by lifegems great answer technoid!

[Regenallotment]

this is fascinating, thanks so much. Explains a lot for me and my low stomach acid when diagnosed AIT and how my B12 issues are linked, I wonder if over negative regulation of Hcl secretion was what happened there 🤔

[EllaNore]

Wow technoid as I started listening to this it started to make sense that stress anxiety and depression could break down the acidic pH balance in your stomach causing your mucosal lining to be damaged and your parietal cells to be damaged. This shows 100% that stress anxiety and depression can lead to illness and even lead to pernicious anemia. I was under an exorbitant amount of stress for decades. I was under extreme mental abuse and I started getting sicker and sicker and sicker. I truly believe that the damage done to my abdomen by a dog and all the proceeding surgeries, and then the stress of not being 100% and not being able to work, pay bills, not have children ever, and being sick, and the stress of family and friends not believing you, and the stress of just being sick itself and life itself, I really think snowballed everything. I sure wish happiness could reverse it all because Id do anything to reverse what happened to me, as I know we all would. Is stress a common denominator with all of us? One has to wonder. Talking to a few people on here through the years, it's clear to me that stress was probably a major part of their life and abuse. Are we all sick because of the stress and depression in our lives?Another interesting point on this was the mucus. The thick and the thin mucus. I have extremely thick mucus my blood is thick everything seems to just be thicker, even my face is puffy and swollen my legs my whole body. Just ever so slightly swollen all over. And the thick mucus that I make is really a huge inconvenience. I can't cough it out, which coughing probably led to a hietal hernia. I'm wondering if stress makes you secreate more mucus than you're supposed to. They haven't diagnosed why my blood is thick yet because I have to wait 3 months and be tested again. It wasn't enough that I've been suffering for years they need me to wait another 90 days. I believe that's because it takes 90 days to rejuvenate red blood cells. And by that time they'll be able to tell whether or not it was a temporary thing from medication or a full-time thing. Which I don't understand why they need to wait 90 days with the rest of my symptoms. I'm hoping that if they give me blood thinners or whatever it is that I'll need that I'll be able to breathe again and be able to walk better and get my life back. Because B12 is done all it's going to do for me and I feel pretty good with the B12 but the inability to walk Breathe Right, not be completely fatigued and exhausted. That has to do with the thick mucus and the thick blood. Which I think according to this video was caused by stress anxiety and abuse. Stress is a terrible thing it will kill you one way or another. With the thick blood it keeps oxygen from getting to every cell in your body which eventually starts killing things off starting with the mucosal lining of my stomach. And then my parietal cells. And then that led to pernicious anemia. What came first? It's hard to say it seems stress is the Catalyst for all of this. I think it's very important that we all try to maintain our stress levels for a lot of reasons to save our lives mostly. I think happiness is a great cure for a lot of things. I believe that we all need to laugh and try to be happier. But when we're sick like this it just is a Snowball Effect. But if we could try to be happier and alleviate the stress in our life, maybe we would feel better eventually.

I hope this makes sense I'm not feeling all that great my brain isn't quite working right so I hope I said this correctly.

Thank you for this Technoid. Very, very, interesting, for me anyway.

[wedgewood]

Thank you Technoid . I will have to listen a few times to take it all in . extremely interesting.So much valuable information!