B12 5mg, is it worth it?

[VMITCHELL78]

Hi, I have b12 injections and have been offered ampoules of 1mls at 5mg.

Has anyone had any experience with these, does it give you a mega boost so I wouldn't have to have as many 1mg injections?

Thanks in advance for any advice

[Wwwdot]

Hi Vmitchell

I have no idea but are you enable to explain who offered you these ? Surely not a GP or medic in the UK?

Hydroxocobalamin? Brand?

🤗🤗🤗

[Technoid]

Strangely enough it might be counterproductive. Curiously! According to this 2021 paper it might be better to inject more frequently (at least daily) but at much lower dosages - similar to how B12 would naturally be taken in. Infrequent high doses seem to be the least effective.

However, I have not come across pre-formulated ampoules that offer B12 in near-physiologic doses (e.g. ~ 30mcg) so I'm not sure how feasible it is to reach physiologic B12 levels with (frequent) low dose injections. In any case, relief of symptoms should be a guide.

The paper had this conclusion:

"when extracellular B12 levels are at physiological levels, the intracellular B12 levels are higher, which is supported by the increased gene and protein expression of receptor/transporter in both in vitro and in vivo models. This shows that at physiological B12 concentration, the active transport of B12 in the tissues accelerate.

Our evidence thus validates the long-existing hypothesis that the cells indeed, regulate the uptake of B12. However, at supraphysiological levels of B12, the intracellular concentrations are relatively reduced, the receptor/transporter get downregulated, presumably to protect the cells from long-term exposure to high levels.

This supports that regular smaller doses of B12 supplementation might be better than larger, infrequent dosing of B12 in deficient individuals. In addition, overloading B12 deficient patients with supplements may not present any additional benefit but regular monitoring of patients to aim for physiological levels may be recommended. This may maintain optimal levels of the transporter/receptor system across various tissues, although this requires additional studies in other tissues."

from:

Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter

ncbi.nlm.nih.gov/pmc/articl...