Choline supplements?

[WiscGuy]

I am wondering whether choline supplement might be helpful in nerve healing. Anyone have any insights?

[wedgewood]

I have read somewhere in my travels for information on B12 deficiency, that choline could be of help in nerve healing . Sorry I haven’t got anything more detailed .

[Littlelodge123]

I actually tried this with supplementation after reading studies on line. Did nothing for me.

[Kapat1]

I read this is supposed to help with fatty liver

[Sunnysidoop]

I take bodybio phosphatadyl choline but because it helps my cognition, to the extent I can't bare not to take it. It's painfully expensive

[WiscGuy in reply to Sunnysidoop]

For general information:

differencebetween.com/diffe...

[WIZARD6787]

B6 was and is very effective for my nerve pain and healing. On this forum I learned that Pyridoxal and Pryidoxal HCL inhibit or prevent the bodies use of Pryidoxal 5 Phosphate and now take 848 ug twice a day with water.

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

Abstract

Vitamin B6 is a water-soluble vitamin that functions as a coenzyme in many reactions involved in amino acid, carbohydrates and lipid metabolism. Since 2014, >50 cases of sensory neuronal pain due to vitamin B6 supplementation were reported. Up to now, the mechanism of this toxicity is enigmatic and the contribution of the various B6 vitamers to this toxicity is largely unknown. In the present study, the neurotoxicity of the different forms of vitamin B6 is tested on SHSY5Y and CaCo-2 cells. Cells were exposed to pyridoxine, pyridoxamine, pyridoxal, pyridoxal-5-phosphate or pyridoxamine-5-phosphate for 24h, after which cell viability was measured using the MTT assay. The expression of Bax and caspase-8 was tested after the 24h exposure. The effect of the vitamers on two pyridoxal-5-phosphate dependent enzymes was also tested. Pyridoxine induced cell death in a concentration-dependent way in SHSY5Y cells. The other vitamers did not affect cell viability. Pyridoxine significantly increased the expression of Bax and caspase-8. Moreover, both pyridoxal-5-phosphate dependent enzymes were inhibited by pyridoxine. In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5'-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

[Technoid]

I've read some papers on animal studies that found Choline (CDP-Choline) to be useful in nerve regeneration. Alpha-GPC is another commonly recommended Choline form. I have tried both and cannot say I noticed much nerve impact. I also tried phosphatidylserine 100mg but its quite expensive ... I cut down a lot of my "extra" supplementation.

Soya Lecithin is a fairly cheap way to get extra Choline, I do use this, at about 2 tsp a day, mix into granola so it cant really be tasted.

Choline has some controversies around it regarding TMAO production but that is a minefield to get into...

[WiscGuy in reply to Technoid]

I started sort of a "trial" of CoQ10 after reading your comments in a recent discussion of supplements. (I used quotes because I am collecting no data.) I remember mention of Soya Lecithin, and I will probably try it. Would a 1-pound container of granules be a good way to start?

[Technoid in reply to WiscGuy]

Should do. I have a naturally low choline diet (vegan) so I'm not personally worried about a bit of extra choline but obviously still following the research on supplementing it.

" the form of choline seems to matter, with greatest risk of elevated TMAO levels seen for free choline (i.e., choline bitartrate) and low to no risk found with forms of choline such as phosphatidylcholine or lecithin."

from

consumerlab.com/answers/do-...

[WiscGuy in reply to Technoid]

Thank you.