I was diagnosed with Pernicious anaemia In 2015 so I probably have had it for years before.
After initial intensive daily treatment I have had a monthly injection since then.
when I run over time I have numbness and tingling in my hands .
IRecently had a b 12 injection and three days later I have experienced tingling and numbness in my hands and arms. I have also noticed some uncharacteristic memory loss and confusion- slight but noticable.
I also have an Aortal Valve leake diagoised in 2019.
Are they linked and why is my condition exibiting pre Injection symptoms post injection?
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Ossoryhill
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From what I've read on various forums, it's not unheard of to spontaneously start needing more frequent injections. Perhaps all along they were not frequent enough and it finally reaches a tipping point (my own hypothesis). A trial of more frequent injections could be useful.
Or it could be a folate issue - some people go low without supplementing and/or need more than others. Though I suppose you would've run into this problem long ago.
Heat or light damage is another thing I always mention when people say injections no longer seem to be as effective.
I don't know of a connection with aortal valves but others might.
It might be worth trying more frequent jabs - at least that's a safe option - to see if it helps or to rule it out.
Are you missing and other nutrients? Folate, potassium, magnesium, iron and Vitamin D are the main ones but all vitamins and minerals, particularly the the B vitamins, are essential for the efficient working of B12 in nerve function, energy release and cell repair.
Ideally you will get them from your diet but depending on what has caused your B12 deficiency, you may need to supplement.
I have a prolapsing tricuspid valve (much less serious than an aortic one) and I get numbness and pins and needles, particularly in my arms, at night. At times I have heart block arrhythmias too but I'm not convinced that they are directly linked to the heart valve problems.
I've been doing daily SI for 7+ years so mine is not due to a lack of B12 but I have fairly extreme malabsorption problems so it could be due to other deficiencies causing issues with the processes that use B12.
Not a medic Osseryhill but, as you’ve had PA for many years, it’s highly possible that monthly injections have not been enough and you need more frequent injections, which is why many of us on this forum self inject, in order to prevent further symptoms and heal existing. You’ll find lots of information and recommended reading here and by joining the PAS.
Re. leaky valve (p.f.o), I’m wondering if you’ve had thyroid testing? Research reveals that 40% of those with B12def/PA also go on to have thyroid disease, and vice versa. Four in our family have both.
At one time, a scan I’d had done revealed two leaky valves, but, after optimal thyroid treatment, a further scan revealed only the one I’d had since birth, which I’ve read is quite a common condition and, interestingly, may be connected to migraine with aura.
Hi Polaris , very late reply to your post here but I stumbled across this today . Fascinating because I was born with sub aortic stenosis , ( narrowed aortic valve). I suffered with aura migraines since age of 14 and was diagnosed with PA . Can’t all be coincidences can it?
Hi Osseryhill, very late reply to your post but I stumbled across this and had to comment. I was born with aortic valve stenosis( narrowing and leaky valve, had aura migraines since age 14 and now diagnosed PA which I’ve prob had for years .Wondering if there’s a connection too
I agree no coincidence Osseryhill ! It was my son, studying for diving instructor exam, who discovered and told me about the research connecting a pfo with leaky valve and migraine with aura. It seems to have skipped a generation in our family but my granddaughter has this condition - alas, though with v. sick headaches……...
I’m very old now, having regularly taken a Garlic, Hawthorn & Vitamin E supplement, and learned to avoid red wine, chocolate, tomato and cheese all on the same day, as this always seemed to set it off. Stress was another trigger.
Interestingly, I can’t remember having this condition at all since thyroid and B12 medication has been optimal 🤔
Would be interesting to research this further - best wishes for good health x
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