Would high dose of oral b12 cause other problems?

[lesbud1]

If you had to take 1000ug oral b12 daily to be able to absorb 2-4ug daily what would the 998ug do. presumably faecally removed but would that upset your stomach, bowels? anyone know?

[wedgewood]

Any unabsorbed B12 would be filtered out through the kidneys and passed into the urine .

[fbirder in reply to wedgewood]

No. If it's unabsorbed it doesn't get into the blood.

[deniseinmilden]

To stabilise and repair lots of damage from long term (20 to 30 years) deficiency that seems to have caused problems with absorbtion and matabolism I need lots of B12.

When I was using 1mg in 1ml ampoules from the NHS this was not enough to reduce my symptoms and I was using around ten of the 5000 mcg sublingual "lozenges" (tablets), plus sprays, to make up the difference every day.

This was expensive and a pain to make sure I had enough with me, was constantly taking them, etc, but they had no ill effects on me.

After about 4 months I had improved enough that my brain was able to take on the challenge of ordering online and I then bought my own 1.5mg in 1ml ampoules and didn't need the sublinguals any more.

The only problems I can envisage would be if you were intolerant of any of the other ingredients or, if they worked well, and you were using the methylcobalamin ones you might end up getting too much methly and it giving you a headache. You could try to get the ones with really simple base ingredients (eg Solgar ones but there are others) or maybe the cyanocobalamin ones. I didn't ever find any hydroxocobalamin ones.

Nothing beats more injected B12 though.

[Technoid in reply to deniseinmilden]

For anyone rediscovering this thread, you can get Hydroxocobalamin Sublinguals (from a Canadian company called AOR) here, but they are only 1k mcg. pasioonline.com/en/b12-hydr....

[fbirder]

ANy unabsorbed B12 will pass into the large intestine. There it will be used by many bacteria who will convert it into other corrinoids (B12-like molecules that have no biological activity in human). Large amounts of B12 may change the ecology of the gut, promoting the growth of some bacteria sciencedirect.com/science/a...

[lesbud1 in reply to fbirder]

so would that be bad or good?