Any link between PA and Methotrexate? - Pernicious Anaemi...

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Any link between PA and Methotrexate?

Paolini_Teracini profile image
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Anyone know any link between Methotrexate and PA?

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Paolini_Teracini
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Gambit62 profile image
Gambit62Administrator

There does seem to be a link between methotrexate and folate

nejm.org/doi/full/10.1056/N...

and as low folate can affect uptake and processing of B12 ...

It would also appear that methotrexate can affect the liver - not recommended if there is liver damage - especially caused by alcoholism - and as the liver is an important part of the process for storing and processing B12 I guess there is a possibility that it could lead to B12 problems through that mechanism.

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