P A & high levels of b12 what does it mean

[Crawford1961]

Hi had blood results yesterday & my b12 was 2000 so how can that be when I have pa ? Having so many neurological symptoms & feeling so bad wondering if it could be multiple scerosis Help

[Gambit62 Administrator]

Notice from your other post that you have been on shots for 7 years. If that is the case then a serum B12 test is pretty meaningless unless it shows a really low result.

The serum B12 test just says how much B12 there is in your blood - it doesn't say what types of B12 are there - eg if you are managing to convert hydroxo to methylated forms. It says even less about what is happening with B12 at the cell level.

Yes, there may be other things going on - unfortunately autoimmune problems tend to come in clusters so really not outside the realms of possibility.

Another possibility is a functional B12 deficiency - ie high in blood but none actually getting through to cells in a useable form because of another auto-immune response that tries to shut down the transport mechanism (antibodies to TCII. The only thing I have come across in terms of treating this in people with a B12 absorption problem is a paper by a neurologist in Oxford who reported that patients seemed to respond well to repeated high doses of B12.

Although I haven't had this tested out it certainly seems to fit with my own experience - which is one of running out of B12 within 24 hours of a shot ... though by taking large doses (mainly nasal sprays) I manage very well.

[Gambit62 Administrator in reply to Gambit62]

This is the study I referred to

ndcn.ox.ac.uk/publications/...

[Crawford1961 in reply to Gambit62]

Dr is now getting more bloods done as I have had low vit d for years & think I'm being referred to neurologist so hopefully they will get to the bottom of it !! Think I might order nasel spray in the meantime !! Thanks ror your imput x

[Gambit62 Administrator in reply to Crawford1961]

Yes, the Vit D certainly wouldn't have helped things.

Hope you get everything sorted and feel much better soon

[19191919]

I would see your GP and get a referral to a neurologist who can look at it in more depth. y ou need to sort it out. Good Luck x

[Crawford1961 in reply to 19191919]

Thanks👍🏼 I will have to !! they rang today to say they are stopping my jabs they said I'm drowning in b12 tried to argue but they were having none of it 😞

[Hidden in reply to Crawford1961]

My doctor has done just the same Crawford1969 he did send me for an MRI and once I get the results of that and speak with the doctor again if I get no joy I shall change doctors, I can't leave my health it the hands of an idiot anymore, that idiot doesn't have to live with the pain. I so understand your frustration.