[The role of thiamine in neurodegenerative diseases] [Article in Polish] Irena Bubko et al. Postepy Hig Med Dosw (Online). 2015

[Gioc]

Abstract

Vitamin B1 (thiamine) plays an important role in metabolism. It is indispensable for normal growth and development of the organism. Thiamine has a favourable impact on a number of systems, including the digestive, cardiovascular and nervous systems. It also stimulates the brain and improves the psycho-emotional state. Hence it is often called the vitamin of "reassurance of the spirit". Thiamine is a water-soluble vitamin. It can be present in the free form as thiamine or as its phosphate esters: mono-, di- or triphosphate. The main source of thiamine as an exogenous vitamin is certain foodstuffs, but trace amounts can be synthesised by microorganisms of the large intestine. The recommended daily intake of thiamine is about 2.0 mg. Since vitamin B1 has no ability to accumulate in the organism, manifestations of its deficiency begin to appear very quickly. The chronic state of thiamine deficiency, to a large extent, because of its function, contributes to the development of neurodegenerative diseases. It was proved that supporting vitamin B1 therapy not only constitutes neuroprotection but can also have a favourable impact on advanced neurodegenerative diseases. This article presents the current state of knowledge as regards the effects of thiamine exerted through this vitamin in a number of diseases such as Parkinson's disease, Alzheimer's disease, Wernicke's encephalopathy or Wernicke-Korsakoff syndrome and Huntington's disease.

pubmed.ncbi.nlm.nih.gov/264...

google.it/amp/s/www.researc...

[KERRINGTON]

This article is a great find !

[WinnieThePoo in reply to KERRINGTON]

Are you able to read Polish? It would appear that we should ensure that for neurological benefits we should ensure we sre not deficient in thiamine by ingesting 2mg per day. Not 8x500mg

[Gioc in reply to WinnieThePoo]

Things go on Winnie.

[faridaro in reply to WinnieThePoo]

I can read Polish but don't see the link to the original article.

[Gioc in reply to faridaro]

Ciao, complimenti per la conoscenza delle lingue

Ecco il link:

phmd.pl/api/files/view/1164...

buon Natale!

gio

[faridaro in reply to Gioc]

Thank you, Gio!

Here is translation regarding thiamine and PD:

"A link between thiamine and PD has been shown in recent scientific reports [36]. The demonstrated correlation between the occurrence of the disease and low concentrations of thiamine in the blood suggests that its administration may positively affect the course or progression of the disease.

The administration of thiamine causes the release of dopamine [39].

Genetic research has identified areas of PD-related genes, the changes in expression of which correlated with thiamine concentration. These genes are responsible for glutamate transporters (EAATs) and the α-ketoglutarate dehydrogenase complex (KGDHC) [39].

In studies where thiamine was used in combination with acetazolamide, patients with PD have shown improvement in their condition as assessed by the Scale of Involuntary Movements (AIMS) and reduction of symptoms of dyskinesia and parkinsonism [2,39].

The studies by Luong et al. have shown that the daily dose of thiamine 100-200 mg improved motor function in patients with PD [40]. Costantini et al. carried out thiamine therapy in three PD patients who were assessed on the UPDRS scale (Unified Parkinson's Disease Rating Scale) [10]. Thiamine was administered parenterally 2 times a week, tests were performed after 15 days. Just like Luong et al., the authors noted an improvement in motor skills."

[Gioc in reply to faridaro]

Brava Faridaro!!!la tua capacità di comprensione è veramente spettacolare!

Thank you very much! 🥇

Gio

[faridaro in reply to Gioc]

My pleasure, glad you discovered this article Gio!

[KERRINGTON in reply to WinnieThePoo]

Actually I was happy to see this article because the info backs up Dr C's work on HD Thiamine HCL.

[WinnieThePoo in reply to KERRINGTON]

How? I can't read the article, only the abstract, and that says thiamine is important but nothing about high dose over-supplementation. It talks about needing 2mg a day. Dr C recommended injesting 4000mg a day. Thats not much in common

[Gioc in reply to WinnieThePoo]

phmd.pl/api/files/view/1164...

Buona lettura. LOL

[Gioc in reply to Gioc]

I told you right away it was in Polish.

[WinnieThePoo in reply to Gioc]

Grazie Gio ma parlo solo un po 'di italiano e non di polacco

[Gioc in reply to WinnieThePoo]

Ok Solo che io non voglio essere troppo serio è Natale, un po di leggerezza non guasta!

Buon Natale a te e alla tua famiglia.

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(b1 100mg IM 2x week)

[WinnieThePoo in reply to Gioc]

Gio - Happy Christmas to you and your family too

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The article wasn't referring to 2mg a day IM = 14mg a week (still a lot less than 200mg IM per week)

It was referring to 2mg a day, 14mg a week, ingested, which compares with Dr C's ingested alternative, as taken by Royprop and others of 4000mg a day 28000mg a week

non è lo stesso :-

😉

[rescuema in reply to WinnieThePoo]

Low dose RDA thiamine does not work for many people lacking in transporters activities for active transport. A high dose is required for passive diffusion to pass the BBB, at least until the transporter activity recovers slowly necessitating dose adjustments over time.

[WinnieThePoo in reply to rescuema]

I didn't say it did. I was just pointing out that the abstract for this paper, whilst discussing thiamine had nothing to do with the Dr C therapy

[rescuema in reply to WinnieThePoo]

How can you not see Dr. C's high dose thiamine therapy has something to do with it? He was a neurologist and understood the mechanisms of thiamine's neurological benefits (more so related to the devastating deficiency) and applied the protocol for his patients.

[WinnieThePoo in reply to rescuema]

This paper discusses thiamine but at no point discusses high dose thiamine at least, not in the English abstract.

[rescuema in reply to WinnieThePoo]

You can learn about it here. ncbi.nlm.nih.gov/pmc/articl...

[WinnieThePoo in reply to rescuema]

I have learned about it in many places. That doesn't change the fact that the abstract of an article none of us can read brings nothing to the party

[rescuema in reply to WinnieThePoo]

Well, I hope it explains the therapeutic dosage.

[WinnieThePoo in reply to rescuema]

Hope so!Does it?

What does it say is the therapeutic dose?

What's the explanation?

[rescuema in reply to WinnieThePoo]

Pertaining to -

"It was referring to 2mg a day, 14mg a week, ingested, which compares with Dr C's ingested alternative, as taken by Royprop and others of 4000mg a day 28000mg a week"

[WinnieThePoo in reply to rescuema]

That is the well established level of thiamine ingestion to avoid deficiency. It has nothing to do with therapeutic. And if it did it would directly contradict Dr Cs hypothesis that even where blood thiamine levels were conventionally optimal but massive over supplementation was therapeutic

Did you read the abstract? It was in English and not very long

[rescuema in reply to WinnieThePoo]

Even if the serum level is normal, you can and often still be deficient past the BBB because of genetic deficiency or lacking transketolase activity. If you want to learn more, read Dr. Lonsdale's work. I've commented on this topic many times on this forum as well in the past. You can also visit hormonesmatter.com/ for more relevant detail.

amazon.com/Thiamine-Deficie...

[WinnieThePoo in reply to rescuema]

So what's the amazing revelation from this Polish paper I'm missing?

[rescuema in reply to WinnieThePoo]

Assuming you're genuinely interested, you should be able to gain insight from the study that has relevance once the deficiency (esp past the BBB) is addressed for PD, including the release of dopamine.

Here is faridaro 's response above again in case you missed it -

healthunlocked.com/parkinso...

[Astra7 in reply to WinnieThePoo]

I agree. Quite a different conclusion.

[Kia17 in reply to KERRINGTON]

Well said Kerrington. I am so happy to see thousands of people around the world are enjoying benefits of HDT including myself. There are however some people who may not get benefits from the treatment but it doesn’t undermine the work of late Dr Costantini and his great contribution to our quality of life.

[Kia17]

Thank you Gio

[chartist]

Nice find, Gio. I remember Dr. Costantini said that almost without exception, when he first started some of his patients on B1, he would test their B1 levels prior to starting them on B1 and he said they were almost always in range, but once he would start them on IM B1 and he would retest them, their B1 levels were off the charts. He speculated at the time that the possibility that the transport mechanism was perturbed and HDT was possibly compensating for the defective transport system, but this is why he tried to see about getting a study started to see if his theory was correct, but he an out of time for such a study. He said in time he mostly stopped testing B1 levels.

Art

[Gioc in reply to chartist]

Thanks Art, when we talk about optimal levels or thiamine deficiencies we forget that the body is not a uniform mass, but is made up of organs; in particular the brain is protected by the BBB. So the optimal level where? Thiamine is known to be depleted rapidly and this can lead to organ deficiencies although it is not detected.