My husband was diagnosed with Parkinsons in 2016, of course it took a long time to get meds adjusted. But finally doctor put him on 3 tabs x 7 times a day = 21 pills. I will admit that did seem to stop his tremors, but concerns me he is on such a large dosage this early into the disease. I contacted Dr. Constantini about Thiamine dosage, but have not been able to convince my husband to take it, his excuse his he already takes so much medicine and he does. In addition to carbo/levo he has other meds he takes for other ailments. I am also concerned as he seems to begin to have more off periods now and absolutely has no stamina any longer to complete simple task. Just wondering if anyone else takes this much. Thanks for any replies and information I get.