Exenatide update

[Ianfrizell]

Hi all

This is a link to my vlog, which is an update on my fight to get exenatide on prescription for PD.

youtube.com/watch?v=9phQeSz...(Not working as expected?)

Cheers,

Ian

[M1tz1]

How frustrating for you, Ian. You're in my prayers.

[francis6]

Exenatide is a drug developed to control blood sugar levels for T2 diabetics. While it is not available to PD patients it seems sensible to follow dietary / exercise programs that have been shown to control blood sugar levels.

[WinnieThePoo in reply to francis6]

There's probably no harm in that advice, but they're not equivalent. Exanatide is a glp1 receptor agonist and its action in PD is thought to be due to it's action on glp1 receptors in the brain, rather than by its blood glucose lowering effect. I participated in a live webinar for the drug last year and put that specific question and received that reply from Dr Tom Foltnie.

Good luck with your quest Ian. I couldnt even have it prescribed in France. At least you can get an open label private prescription in the UK. But the drug is expensive, and I am hoping the BIIB054 drug I am hoping to trial, will be at least as effective.

[francis6 in reply to WinnieThePoo]

That is a theory but no-one actually knows why it works. It has also been shown that up to 80% of PD patients have some form of insulin resistance (or, as it should be known, carbohydrate intolerance). The scientists have been trying to explain PD via a bio-chemical approach for the last half century, without success, whilst cases of illnesses like T2 diabetes and PD have risen alongside increasing obesity in a world awash with sugar and near sugars. Captain Cook didn't wait for scientific validation before acting and I would rather move to a "more natural" approach, that has already given me health benefits, rather than put my hopes on a drug breakthrough.

Anyway, we must all do what we think best so good luck with your trial quest.

[WinnieThePoo in reply to francis6]

Did you see Kia17 post about butyrate? The exanatide trial measured blood glucose levels and found no correlation with the results