nortriptyline : Longtime antidepressant could slow Parkinson's

[aspergerian]

Longtime antidepressant could slow Parkinson's

sciencedaily.com/releases/2...

Scientists now have early proof that an antidepressant drug that's been

around for more than 50 years could slow the progression of

Parkinson's.... "What we've essentially shown is that an already

FDA-approved drug that's been studied over 50 years and is relatively

well tolerated could be a much simpler approach to treating the disease

itself, not just the symptoms," Collier said....

[aspergerian]

More from same article.

Collier then began testing rats with the tricyclic antidepressant

nortriptyline and found that it indeed was able to decrease the amount

of abnormal protein that can build up in the brain. This protein, known

as alpha-synuclein, can cause the brain's nerve cells to die when in a

clustered state and is a hallmark sign of the disease.

[Xenos]

Does anyone know if Amitriptyline has the same properties (it's an old tricyclic antidepressant as well) ?

A very experienced French neurologist advised me in March this year to try it... and then very slowly to let go of L-Dopa.

[aspergerian in reply to Xenos]

See amitriptyline discussion.

healthunlocked.com/parkinso...

[Xenos in reply to aspergerian]

Thanks Aspergerian, and thank you also a lot for sharing your scientific watch.

[Bradyboo in reply to Xenos]

Hi..I was on Amitriptyline...I don't have Parkinson's. . however I was on Amitriptyline and found it gave me a hangover effect..very sleepy in a.m. so Dr put me on Nortriptyline. She said it's a cousin to the Amitriptyline. I had a much better reaction to it...no sleepy in morning. Hope that helps.

[Ruffinglgo]

Very informative. Thank you!

[grower]

Well thanks for making my morning My dr has had me on a low dose ever since I got diagnosed, initially to help me sleep.