I am new to Rytary and am having mixed results. Works sometimes other times not. The Doc wants me to go up to 3 - 23.75--95 4 times a day. I was taking 1 - 100/25 only 2 times a day for 12 years with minimal off time. I really didn't know what off time was until I just fell apart in the last month. I took 3 rytary when I woke up and that works but then the next dose I experimented with 1 rytary and 1 100/25 and it worked. No down time. Is it ok to mix the two and am I not getting far less dopa this way. I don't understand the doc's reasoning for 12 Rytary/day. Any thoughts?