The Rytary Saga..

[beehive23]

I have reduced my rytary load by 1/4th....thats 3 caps of 23.75-95mg. Dystonia...better, dyskinesias...better....sleep...slept through the night for the first time in months...ppain..decreased commensurately with the dystonia. Holy cow! what a ride...hang tough folks! cheers.

[LAJ12345]

See if you can switch from rytary to madopar rapid tablets. Or sinemet rapid. They can be cut up so you can get the right dose at the right spacings. Ask the doctor how to transition.

[beehive23 in reply to LAJ12345]

i was on sinemet ir but thanks ill look into the madopar...ive spent 15 years setting up my own med regime..i never let my dr's tell me what meds to take....here in jerkwater the dr's dont have a clue...thanks for the tip. hang tough.

[Juliegrace in reply to beehive23]

I’m pretty sure madopar is not available in the US.

[LAJ12345]

Sinemet rapid tablet would do if madopar isn’t available. It is the long lasting nature that I think might be the problem as I think it takes quite a long time to reach equilibrium and so it is easy to slowly build up to a higher dose than you realise.If you can, get some of the rapid one. Then try and space the current slow release out further in the day and drop the last one in the day add a half or quarter of the slow ones in the middle of slow doses so you don’t bottom out between doses. Keep spacing the slow ones further and further apart then drop another , increasing the rapid ones in the middle to replace them until you have eliminated all the slow ones. Don’t do a sudden change.

How many slow ones are you taking currently and what is the timing? You say you’ve reduced by a quarter? Aren’t these in capsules that can’t be cut? If you are cutting the capsule I think you might be getting a big hit all at once as you have broken the barrier that dissolves slowly?

**edit I just saw you can open and sprinkle on apple sauce so maybe it doesn’t use the capsule casing to slow it down? The madopar version you aren’t supposed to cut.

[Juliegrace in reply to LAJ12345]

By “rapid tablet,” do you mean immediate release?

[LAJ12345 in reply to Juliegrace]

Yes, just the ordinary one

[beehive23 in reply to Juliegrace]

yes sorry immediate release=IR sorry ......we start to forget and use pd slang...yeesh hehehe. and now i see your replying to LAJ sorry again. i have pd brain...

[beehive23 in reply to LAJ12345]

very good points.......it can be sprinkled on applsauce but you must not chew it as the mechanism to slow down the release is enteric coating on a % of the tiny balls in the capsule if you chew it as with every enterically coated time release med , it will speed up its release, also the timing of our pd slowed stomach emptying can cause stacking or od. iam now down to 3 caps rytary 3 times a day down from 4caps 3x day. i have been on sinemet for 15 yeas. ive tried many adjunct therapies but they usually have ended up with too many - side effects for me. the mixed use of sinemet and rytary is contraindicated by the manufacturer as the conversion is not 1:1. see the conversion tool here...........dosingrytary.com/landing.ht... tough thanks for your info!

[beehive23 in reply to beehive23]

to find the tool if the link is broken search rytary dosing tool then follow the directions to convert, this is the tool the dr use or dont as the case may be..try this if u cant find it on search this one works...originalText rytaryhcp.com/dosing?&utm_s...

[LAJ12345 in reply to beehive23]

Oh well if you can decrease the way you are doing it and feel better keep going! You are on the right track.

[beehive23 in reply to LAJ12345]

agreed..

[slimweiss]

My husband takes two different dose amounts of Rytary together 4 times a day - 95mg and 245mg. I wonder if this is too much. I read on HU about those that take far less and have had PD for years. He was diagnosed 3 years ago (although I'm thinking he's had it longer).

[beehive23 in reply to slimweiss]

all i know for certain is if you dose more than every 8-9 hours per the physician's desk reference (usa dr bible on meds) and the rytary manufacturer website that dosing more often then 3 x in a 24 hr period you will open yourself to od ing because the dose does not leave your body until 8-9 hrs...if you dose more than 3x a day you will "stack" on top of the most recent dose...its kind of like drinking too much alcohol and before you sober up you drink more..the AA i believe they call this "binging".........i am not a dr im not giving directions on what to do im just repeating the consensus of pdr and manufacterers website ........hang tough....

[beehive23]

ive had pd for 20 yrs...... or more.......im assuming perhaps wrongly...that you have a personal experience with with something that bothers you bout the result of your husbands current dosing?....hang tough...