About Nilotinib

[silvestrov]

Yea I know, I am on hiatus, but I am rendering video files which take about 2 hours to make 1 and I was bored (blah, blah, blah....). Threads on Nilotinib has been posted often on this site (dating back 3 years) and I decided to investigate it a bit. When you read this thread you will understand why I posted this important information.

CPT Collaborates to Assess the Clinical Use of Nilotinib in Parkinson's

cureparkinsons.org.uk/news/...

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Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance.

ncbi.nlm.nih.gov/pubmed/177...

Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-κB and p53 modulation

"We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused elevation of intracellular reactive oxygen species and that the antioxidant N-acetylcysteine blunted xanthohumol-induced events."

"As structural mutations and/or gene amplification in Bcr-Abl can circumvent an otherwise potent anticancer drug such as imatinib, targeting Bcr-Abl expression as well as its kinase activity could be a novel additional therapeutic approach for the treatment of Bcr-Abl(+) myeloid leukemia."

herbalextractcn.com/info.as...

Raising intracellular reactive oxygen species in cancer cells is an attempt to kill them. NAC blunted this effect.

With investigation, I found that NAC is not good to take if you have cancer:

N-acetyl-cysteine (NAC): good for some things but dangerous with cancer.

denvernaturopathic.com/NAC2...

So if you have any form of cancer, do not take NAC.

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What is xanthohumol?

"Xanthohumol (Xn) is a Bioactive Flavanoid Antioxidant molecule found in the flowering Hops Plant. It is 200 times more powerful than Resveratrol, the world renowned Antioxidant found naturally in Red Wine."

xanthohumol.com/

Beer compound could help fend off Alzheimer's and Parkinson's diseases

"In lab tests, the researchers found that the compound could protect neuronal cells and potentially help slow the development of brain disorders. The scientists conclude xanthohumol could be a good candidate for fighting such conditions."

sciencedaily.com/releases/2...

Can you purchase xanthohumol?

swansonvitamins.com/swanson...

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The file is completed.

Rich

[Serenity_finaly-1]

I knew you were going to miss us.

[AmmieM]

Thank you so much. I just orderEd the supplement

[999---666]

i'm not going to bother you.

[silvestrov]

Here are several additional Xanthohumol supplements:

"Meridium is a patented, water-soluble formulation that makes Xanthohumol readily ingested and metabolized."

It is more expensive than the Swanson supplement and the following link has too much hype for my taste but it may be a better supplement:

meridium.us/?AFFID=138234&s...

And,

HOPS X FACTOR (Lucedin) 50ML in MIRON GLASS

sacredchocolate.com/HOPS-X-...

And for those of you with a sweet tooth for chocolate (and don't mind spending 10.00 on a chocolate heart with xanthohumol):

INGREDIENTS

*Unroasted Cacao Nibs, *Maple Sugar, *Unroasted Whole Cacao Beans with SKINS, *Cold Pressed Cacao Butter, HOPS EXTRACT (15mg Xanthohumol).

sacredchocolate.com/longevi...

The 15mg xanthohumol content is three times the amount in the Swanson brand supplement.

[zawy]

That's interesting that a beer hop chemical acts like nilotinib because it has been theorized that the hops are the reason beer but not other types of alcohol reduce incidence of PD.

[silvestrov in reply to zawy]

When searching for a natural alternative to nilotinib, xanthohumol stood out like the 500 pound gorilla in the corner of the room. After establishing its similarities to nilotinib and imatinib I searched for the PD connection and it all made sense after finding the article about beer/xanthohumol and PD.

I alternate natural supplements and after I cycle through Ecklonia cava I am going to take xanthohumol. Ecklonia cava, though not as good as xanthohumol, is also a good supplement for PD and has been shown to be neuroprotective from many of its ingredients which include...

fucoidan:

researchgate.net/publicatio...

and,

mannitol:

"Fungi, bacteria, algae, and plants make mannitol,"

centralohioparkinson.org/im...

The following is an ad for a ecklonia cava product (but the information is good to have):

"This brown seaweed was packed with more antioxidants than anything found on dry land. And these antioxidants were up to 100 times more potent than land-based anti-oxidants such as blueberries, green tea catechins and even resveratrol."

advancedbionutritionals.com...

It is good to have options.

[glenandgerry in reply to silvestrov]

silvestrov Ecklonia cava looks like a great supplement for PWP but I've just ordered Xanthovital so will see how Glen gets on with that first. Like you say.....it's good to have options

[zawy in reply to silvestrov]

Did you see any results from the xanthohumol? I have taken an interest in it especially since it is supposed to help sleep. Hops contain about 0.5% and I just ordered a 250 gram bag for $15, so it's like 250 doses of the 5 mg in the Swanson product that costs $20 for 90 pills, and isn't currently available. The high-hop beer a poster mentioned that had a big effect on him (where other beers did not) maybe have had 1 mg per beer and he drank four as his test (before he knew about xanthohumol) is like a 5 mg dose.

Also, GM1 has been shown in phase 2 trial to be possibly the best known treatment for PD "reversal". The problem is that it requires FDA approval to extract it from the brains of sheep bred especially to produce it. There is a paper that says a BCR/ABL inhibitor works by "activating" GM1. So this is the third line of evidence that the BCR/ABL inhibition is good for PD (nilotinib, the beer effect, and GM1 were all noticed without anyone looking for a BCR/ABL effect).

[silvestrov in reply to zawy]

When I posted this I was completely stable symptom wise and fully functional so I did not need to try xanthohumol. I wanted to get the information out there and let others try it to see if it positively effected them. To my knowledge 1 gentleman is taking 98% pure xanthohumol from China at about 2 teaspoons a day (I think) - a huge dose. GM1 modulates BCR/ABL expression and I am glad to learn this. In my doc I covered GM1 noting it treated both Parkinson's and Cerebral palsy just as magnesium prevents pre-eclampsia in pregnant women and cerebral palsy in their new born (and is important to PD too). Here are several environmental articles about magnesium and selenium:

Association of soil selenium, strontium, and magnesium concentrations with Parkinson's disease mortality rates in the USA.

"Given that soil elemental concentration in a region is broad indicator of the trace element intake from food, water, and air by people, implications of the results are that high soil Se and Mg concentrations helped reduce the PD mortality rates and benefited the PD patients in the 48 states."

ncbi.nlm.nih.gov/pubmed/281...

Intracellular magnesium level determines cell viability in the MPP(+) model of Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/263...

[healthabc]

so what to do, given that xanthohumols effect is blunted by NAC? I already take NAC 600mg, 2x daily....

[silvestrov in reply to healthabc]

NAC will not blunt the positive effect of xanthohumol. NAC only effects xanthohumol's ability to produce free radicals inside a cancer cell thus killing the cell. Inside normal cells xanthohumol does not produce a pro-oxidant effect, so NAC will not alter xanthohumol's positive therapeutic effects. Xanthohumol can either have antioxidant activity to remove free radicals from within normal cells, or produce a pro-oxidant free radicals within cancer cells (to kill the cell), and NAC would only prevent the pro-oxidant effect.

[park_bear in reply to silvestrov]

NAC put my chronic prostatitis ("CP") into remission going on about a year now. My personal comparison of PD with CP: PD is a challenge vs CP which is unmitigated abject suicide inducing misery. I am thankful for the PD which got me to try the NAC.

[BUZZ1397]

Switch to beer rich with hops, and live longer?

[BUZZ1397]

Hoppy beer

brewpublic.com/uncategorize...

[silvestrov in reply to BUZZ1397]

Thanks for like link and yes I like 'hoppy' beers. Now I have to find out how many of them are available in western Pennsylvania...

[Greenday]

Xanthohumol has almost identical chemical structure to Nobiletin, another potent flavonoid isolated from citrus peels.

Xanthohumol : C21H22O8

Nobiletin : C21H22O5

Nobiletin have been shown to exhibit neuroprotective effect in multiple in vitro and in vivo studies. Also Nobiletin possesses antileukemia properties equivalent to imatinib .

- Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease.

ncbi.nlm.nih.gov/pubmed/284...

"Nobiletin & Tangeritin may represent beneficial drug candidates for the treatment and prevention of Alzheimer's and Parkinson's disease. "

- Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/253...

- Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice.

ncbi.nlm.nih.gov/pubmed/243...

- Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

mdpi.com/1420-3049/21/10/13...

- Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo

ncbi.nlm.nih.gov/pubmed/268...

- Nobiletin, a Citrus Flavonoid, Reverses Learning Impairment Associated with N-Methyl-D-aspartate Receptor Antagonism by Activation of Extracellular Signal-Regulated Kinase Signaling

jpet.aspetjournals.org/cont...

Nobiletin has antileukemia properties:

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells.

ncbi.nlm.nih.gov/pubmed/268...

Nobiletin & Tangeritin can be found in the market as Sytrinol®, a proprietary formulation

[silvestrov]

Thanks for the research and nobiletin should be tried by PwP. Nobiletin is what I call a 'and' supplement - a supplement which can treat a multitude of conditions simultaneously (like curcumin/tumeric, baicalin/S. baicalensise..... I did another search to see if nobiletin can treat osteo arthritis and there is some in vivo evidence to this effect:

Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.

ncbi.nlm.nih.gov/pubmed/185...

I always look to see if a supplement is good for OE because it is a common problem with the elderly and if the chemical can improve OE, it is truly applicable to elderly problems. I also look to see if it is good for the liver and nobiletin also has in vivo evidence:

Nobiletin attenuates lipopolysaccharide/D‑galactosamine‑induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF‑κB‑mediated cytokine production

spandidos-publications.com/...

This is a handy summation of nobilitin and should not be overlooked by those visiting this site. I will put it on the list of herbal supplements I will try in the future.

[Rhyothemis]

Xanthohumol can convert to 8-prenylnaringenin, which is estrogenic [1]. Some women use hops extract for breast enlargement.

1 - nature.com/articles/s41598-...