About Nilotinib

Yea I know, I am on hiatus, but I am rendering video files which take about 2 hours to make 1 and I was bored (blah, blah, blah....). Threads on Nilotinib has been posted often on this site (dating back 3 years) and I decided to investigate it a bit. When you read this thread you will understand why I posted this important information.

CPT Collaborates to Assess the Clinical Use of Nilotinib in Parkinson's



Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance.


Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-κB and p53 modulation

"We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused elevation of intracellular reactive oxygen species and that the antioxidant N-acetylcysteine blunted xanthohumol-induced events."

"As structural mutations and/or gene amplification in Bcr-Abl can circumvent an otherwise potent anticancer drug such as imatinib, targeting Bcr-Abl expression as well as its kinase activity could be a novel additional therapeutic approach for the treatment of Bcr-Abl(+) myeloid leukemia."


Raising intracellular reactive oxygen species in cancer cells is an attempt to kill them. NAC blunted this effect.

With investigation, I found that NAC is not good to take if you have cancer:

N-acetyl-cysteine (NAC): good for some things but dangerous with cancer.


So if you have any form of cancer, do not take NAC.


What is xanthohumol?

"Xanthohumol (Xn) is a Bioactive Flavanoid Antioxidant molecule found in the flowering Hops Plant. It is 200 times more powerful than Resveratrol, the world renowned Antioxidant found naturally in Red Wine."


Beer compound could help fend off Alzheimer's and Parkinson's diseases

"In lab tests, the researchers found that the compound could protect neuronal cells and potentially help slow the development of brain disorders. The scientists conclude xanthohumol could be a good candidate for fighting such conditions."


Can you purchase xanthohumol?



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9 Replies

  • I knew you were going to miss us.

  • Thank you so much. I just orderEd the supplement

  • i'm not going to bother you.

  • Here are several additional Xanthohumol supplements:

    "Meridium is a patented, water-soluble formulation that makes Xanthohumol readily ingested and metabolized."

    It is more expensive than the Swanson supplement and the following link has too much hype for my taste but it may be a better supplement:





    And for those of you with a sweet tooth for chocolate (and don't mind spending 10.00 on a chocolate heart with xanthohumol):


    *Unroasted Cacao Nibs, *Maple Sugar, *Unroasted Whole Cacao Beans with SKINS, *Cold Pressed Cacao Butter, HOPS EXTRACT (15mg Xanthohumol).


    The 15mg xanthohumol content is three times the amount in the Swanson brand supplement.

  • That's interesting that a beer hop chemical acts like nilotinib because it has been theorized that the hops are the reason beer but not other types of alcohol reduce incidence of PD.

  • When searching for a natural alternative to nilotinib, xanthohumol stood out like the 500 pound gorilla in the corner of the room. After establishing its similarities to nilotinib and imatinib I searched for the PD connection and it all made sense after finding the article about beer/xanthohumol and PD.

    I alternate natural supplements and after I cycle through Ecklonia cava I am going to take xanthohumol. Ecklonia cava, though not as good as xanthohumol, is also a good supplement for PD and has been shown to be neuroprotective from many of its ingredients which include...





    "Fungi, bacteria, algae, and plants make mannitol,"


    The following is an ad for a ecklonia cava product (but the information is good to have):

    "This brown seaweed was packed with more antioxidants than anything found on dry land. And these antioxidants were up to 100 times more potent than land-based anti-oxidants such as blueberries, green tea catechins and even resveratrol."


    It is good to have options.

  • silvestrov Ecklonia cava looks like a great supplement for PWP but I've just ordered Xanthovital so will see how Glen gets on with that first. Like you say.....it's good to have options :-)

  • so what to do, given that xanthohumols effect is blunted by NAC? I already take NAC 600mg, 2x daily....

  • NAC will not blunt the positive effect of xanthohumol. NAC only effects xanthohumol's ability to produce free radicals inside a cancer cell thus killing the cell. Inside normal cells xanthohumol does not produce a pro-oxidant effect, so NAC will not alter xanthohumol's positive therapeutic effects. Xanthohumol can either have antioxidant activity to remove free radicals from within normal cells, or produce a pro-oxidant free radicals within cancer cells (to kill the cell), and NAC would only prevent the pro-oxidant effect.

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