So, now I've started being monitored by a renowned movement disorder doctor and he says I should switch from Sinemet to Rytary for longer periods of control. But first I have to take Azilect for a few weeks. I told them I was also using MP and other supplements and the Sinemet works better with them than with out them. He was aware of the benefits of everything I told him. I am taking the recommendation and I know Azilect is making a non-reversible change to my system. I trust this man and he doctor swears by it, not literally. Still will use MP in morning and evening and EGCG along with all my usual supplements. Today was the 4th small (.5 mg) dose of Azilect and i can't tell any difference. Still taking my normal 1/2 tab of C/L 25/100.