As always, I try different things at the same time so it is hard to judge. This time I took 600 mg NAC twice yesterday thanks to Park_bear's recent post and it was the best day in 2 months. The confounding factors are: I stopped my 7 cups of coffee (1/3 cup of coffee grains in 16 oz) per day due to excessive anxiety and feeling ill and confused about 5 days ago. At that time I also started taking very small doses of an SSRI anti-depressant Zoloft, 5 mg/day. Both of these things have major effects, but yesterday was a leap ahead of my expectations.
I previously bought a pulse oxymeter to measure blood oxygen ($15 Amazon) also based on Park_Bear's suggestion and noticed I was consistently low at about 92 to 95% when people around me were almost always >96%. Also, in playing with the kids and showing them blood under a microscope, I used my blood and my wife's blood. Without thinking about it, we marveled at the time at how much redder her blood was, seeming to have a higher red blood cell count. After months, I finally asked myself how can I get this higher? Doh, iron. Maybe I blocked this thought out in the past because it is part of the complex process that causes damage in PD, and the vast majority of supplements that reduce PD in animal tests are iron-chelators (caffeine, nicotine, gallic acid in black tea...seemingly every PD supplement I checked). However, there was this one annoying abstract seeming to go against the few other abstracts concerning iron that indicated higher blood iron had the least incidence of PD, something like 11x fewer cases which has to be an error, and the wording or my reading of it may have somehow been backwards. So I took a double-dose of iron for a week and single doses since then and the oxymeter has consistently read 96% to 97% since then (2 months?). I checked my blood tests from the past two years and my RBC and iron were indeed borderline on the low end. That seemed to help a lot but then problems returned, which I have now largely identified as a caffeine overdose.
Consistent with the low-iron theory, I have had a strong feeling I was missing something in my diet the past two years, but never specifically felt like eating dirt (clay?) which is a symptom of low iron, at least in cultures that teach it. But as many of my previous posts show, I constantly felt like I was not getting enough oxygen to my brain except during exercise.
I also take nilotinib off and on and the jury is still out for me. That's another confounding factor, along with not being able to be consistent with exercise.
I have not been diagnosed with PD, but have a thumb tremor, no sense of smell, persistent anxiety, essential tremor during emotional stress, and days of confusion and inability to concentrate. Strangely, my balance is better than it was two years ago.
More consistent with non-PD neurological issues, I have absolutely no sense of thirst. (I've also recently started taking salt which I usually never add to meals).