NAC demonstrated beneficial in PD!

This study just published in PLOS One: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data, here: journals.plos.org/plosone/a...

They gave PD patients 50mg/kg NAC via IV once weekly, plus, 600mg capsules 2x day, for 3 months. This was a preliminary study with a dozen patients each in the control and treatment groups. Over the course of the study the UPDRS score in the treatment group dropped by 3 points. For the control group it rose 2 points (lower is better). The effect in the treatment group was statistically significant, as were improvements as measured by DAT scan.

Since most of us are not in a position to get IV NAC weekly it is not clear how much of an effect can be obtained from just oral NAC, however, it certainly can't hurt.

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  • It is cheap enough to put it into your daily program. I have been taking it for years and look how well I am doing. (sorry, what were we talking about again? ) just kidding or am I?

  • Glad you discovered NAC & PD. I have been taking it for years and here is a prior thread on the subject of NAC:

    healthunlocked.com/parkinso...

  • Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease

    This study has been completed.

    "Subjects will be provided 6000 mg/day of N-acetylcysteine (capsule) to be divided into 2 equal daily doses and taken orally for approximately 28 days"

    clinicaltrials.gov/ct2/show...

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    Commentary (from me): I am glad to see a clinical trial for NAC and PD has been completed. Though I wonder why the researchers did not modulate a series of doses to see if NAC was effective at lower doses. In investigating NAC I have found studies in which NAC was effective at the lower dose of the study, for example:

    N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial.

    RESULTS:

    "NAC up to 2.4 gm/day was tolerated by all patients, while 33% of those receiving 4.8 gm/day had reversible nausea. Placebo or NAC 1.2 gm/day did not influence disease activity."

    ncbi.nlm.nih.gov/pubmed/225...

    [N-Acetylcysteine: low and high doses in the treatment of chronic obstructive lung diseases in Chernobyl accident liquidators].

    AIM:

    "To study clinical effectiveness and antioxidant activity of N-acetylcisteine (NAC) in daily doses 600, 1200, 1800 and 2400 mg in Chernobyl wreckers suffering from chronic obstructive pulmonary diseases (COPD)."

    RESULTS:

    "Cough intensity diminished insignificantly. Expectoration improved significantly only after intake of 1200 mg/day NAC. In higher doses expectoration difficulties appeared again."

    ncbi.nlm.nih.gov/pubmed/119...

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    6,000 mg/day given in 2 - 3,000 mg doses. Really?

  • Indeed, that is one heck of a lot. 10 capsules/day for the usual 600mg cap.

  • When an artist can see the flaw in a scientific trial we are all in trouble!

  • Thanks for this info Sylvestro. Here is another link:

    news-medical.net/news/20160...

    I posted yesterday there is a clinical trial for this going on and I am very curious about it.

    Here is the post for the clinical trial

    clinicaltrials.gov/ct2/show...

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