NAC demonstrated beneficial in PD!

This study just published in PLOS One: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data, here:

They gave PD patients 50mg/kg NAC via IV once weekly, plus, 600mg capsules 2x day, for 3 months. This was a preliminary study with a dozen patients each in the control and treatment groups. Over the course of the study the UPDRS score in the treatment group dropped by 3 points. For the control group it rose 2 points (lower is better). The effect in the treatment group was statistically significant, as were improvements as measured by DAT scan.

Since most of us are not in a position to get IV NAC weekly it is not clear how much of an effect can be obtained from just oral NAC, however, it certainly can't hurt.

6 Replies

  • It is cheap enough to put it into your daily program. I have been taking it for years and look how well I am doing. (sorry, what were we talking about again? ) just kidding or am I?

  • Glad you discovered NAC & PD. I have been taking it for years and here is a prior thread on the subject of NAC:

  • Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease

    This study has been completed.

    "Subjects will be provided 6000 mg/day of N-acetylcysteine (capsule) to be divided into 2 equal daily doses and taken orally for approximately 28 days"


    Commentary (from me): I am glad to see a clinical trial for NAC and PD has been completed. Though I wonder why the researchers did not modulate a series of doses to see if NAC was effective at lower doses. In investigating NAC I have found studies in which NAC was effective at the lower dose of the study, for example:

    N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial.


    "NAC up to 2.4 gm/day was tolerated by all patients, while 33% of those receiving 4.8 gm/day had reversible nausea. Placebo or NAC 1.2 gm/day did not influence disease activity."

    [N-Acetylcysteine: low and high doses in the treatment of chronic obstructive lung diseases in Chernobyl accident liquidators].


    "To study clinical effectiveness and antioxidant activity of N-acetylcisteine (NAC) in daily doses 600, 1200, 1800 and 2400 mg in Chernobyl wreckers suffering from chronic obstructive pulmonary diseases (COPD)."


    "Cough intensity diminished insignificantly. Expectoration improved significantly only after intake of 1200 mg/day NAC. In higher doses expectoration difficulties appeared again."


    6,000 mg/day given in 2 - 3,000 mg doses. Really?

  • Indeed, that is one heck of a lot. 10 capsules/day for the usual 600mg cap.

  • When an artist can see the flaw in a scientific trial we are all in trouble!

  • Thanks for this info Sylvestro. Here is another link:

    I posted yesterday there is a clinical trial for this going on and I am very curious about it.

    Here is the post for the clinical trial

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