I have posted this as there are many voices against medication on here but many of us see meds as a life saver despite the problems. It's primary purpose is not to convince those who are convinced meds are bad. It's more to support those who are taking them and to give some reasons why they have made a good decision.
During the past decade, a number of large drug trials suggested that beginning levodopa therapy should be delayed to reduce the risk of motor complications in patients with Parkinson's disease. But is the cause the length of time exposed to levadopa? This research result is interesting.
Over 4 years researwches investigated a large group of patients with Parkinson's disease in a sub-Saharan African country (Ghana), where access to medication is limited and begining levodopa therapy often happens many years after onset. They were investigating whether motor complications (dyskinesia) is primarily related to the length of time on levodopa or to other disease-related factors.
Two groups were compared, one in Italy and one inGhana. Although levodopa was introduced later in Ghana the length of time from having Parkinson disease to motor fluctuations and dyskinesias was similar in the two populations.
The results show that motor fluctuations and dyskinesias are not associated with the length of time on levodopa therapy, but rather with longer disease duration and higher levodopa daily dose. Hence, the practice to withhold levodopa therapy with the objective of delaying the occurrence of motor complications is not justified.