Am seeking experiences and opinions from those who have taken Entacapone, (Comtan).

[ronn]

Entacapone is a COMT inhibitor, prescribed, in my case, to enhance the effects of levadopa/carbidopa. However, after reading the lengthy list of possible side effects and warnings, I'm having second thoughts.

Any opinions would be appreciated.

[Sedona]

While I was taking it, I did not notice any side effects and no real benefit, so discontinued use.

[johntPM]

I have taken Stalevo (together with ropinirole and rasagiline) for 5 years. I think it extended the duration of effectiveness compared to Sinemet, but the change was not dramatic. I have no side-effects additional to those caused by the other PD drugs.

John

[sunshineonacloudyday]

i took Entacapone for almost a year before my dsb surgery. the only side-effect i experienced was a change in the colour of my urine. it boosted the levadopa/carbidopa for. MY neurologist was a pharmacist first. so I feel comfortable with is care. what are your major concerns?

[jmtolani]

I switched from Sinemet 25/100 to Stalevo about 2 years ago and found it to be more beneficial with far fewer side effects.

[leojohn]

My husband has been taking entacapone for over 1year now.

I credit this medication with stopping his tremors.

He did develop a little dyskenesia but I feel the tradeoff is well worth it.

Not everyone reacts the same to medication; so I am just informing you of my husband's response .

I can't say for sure that it extended the effectiveness of the sinemet but certainly not having a tremor is a real bonus.

I don't know if it is unusual to lose a tremor completely but I feel tremor must be a very tiring part of Parkinson's.

All side effects of medications are quite frightening but

Parkinson’s Disease would have severe symptoms without them.

Whether to add another is always a hard decision.

Good luck

[Donzim]

Used it successfully for six months, after which didn't extend the c/l significantly so stopped it. That is probably an individual thing.

[Kachimom]

Funny you should be posting about considering Comtan. My Doctor put me on it just a month ago to see if it would help with the Sinimet but after three weeks my memory from minute to minute was a struggle. If it was helping I'm not sure. Nothing significant for sure but I was still on half dose so not a good judge of its effectiveness. I have tried many other drugs to support Sinimet and have had bad side effects from them too. Guess you need to give it a try for yourself, huh? Everyone is different.

[rustjudge]

I have taken Comtan in conjunction with sinemet and sinemet er and azilect for 7 years with no side effects.

[hanifab23 in reply to rustjudge]

Hi Rusjudge

Please tell me the dosage

[juliog]

I've been taking stalevo for over two years, with several side effects including fainting spells, dyskinesias and severe skin rash in my legs. So I am discontinuing it, replacing it gradually with Mucuna pruriens. I was taking 50 mg 4 times a day and have now reduced it to 100 mg (in two takes), only one day a week. Hope to drop it altogether in the next couple of months

[hanifab23 in reply to juliog]

Please tell me more I need to get off my medication

[hanifab23 in reply to hanifab23]

can I connect with you by email

[margie]

I have taken stalevo ( has entacapone) and have no problem - been taking it for 9 years now.

[joe45]

Hi I've been taking entacapone for abt 2 years no side effects just urine colour which is not harmful 💁🏼

[Kwinholt]

I am taking Comtan and I too was concerned , another pill another side effect. I have the luxury of my dr letting me cut my meds in half to start to see how I feel with them . So. Instead of taking a whole comtan twice a day with my carbo/Levo I take a 1/2 once or twice a day . I also take one azilect with my morning dose of carbo/levo