humira, methoxetrate, citalopram is this a sa... - Pain Concern

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humira, methoxetrate, citalopram is this a safe drug combination?

whitedaisy profile image
4 Replies

My medicine regime widens. Until this horrid diagnosis of Ankylosing Spondilitis I was resistant to taking meds. I am intolerant of many meds and foods. My pharmacist was surprised at my meds regime but I am sure my doctors must know what they are doing? Any comments on the above combination would be welcome.

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whitedaisy
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Calceolaria profile image
Calceolaria

Hello WhiteDaisy. In what way was the pharmacist surprised? If he had any concerns he should have contacted your doc.

whitedaisy profile image
whitedaisy

He said that there could be a problem with methotrexate combined with citalopram. I will be having monthly bloods checks.

Calceolaria profile image
Calceolaria

I know citalopram is a Serotonin based antidepressant as I wanted to try it off label for pain. Unfortunately a side-effect is tinnitus and as I already have that, with bells on so's to speak, I had to give it a miss.

Pharmacists know better than GPs about medicine combinations. I often check with mine just to be sure - like you, I just don't like taking them. Ask the pharmacist if you should get back to doctor about the mix.

I would imagine a huge proportion of people with degenerative and painful diseases are on Antidepressants, so the combination hardly sounds unusual to me. I would check in detail on Cytochrome P450 interactions though, (can't see a specific problem with a very brief look) as these cause a lot more problems than Doctors or pharmacists would have you believe, and both those drugs are involved with a fair few mechanisms of in their metabolism!

I personally have had MANY Antidepressant drugs, including several SSRIs and none of then ever had a 0.001% improvement on pain for me, although they all worked surprisingly well for the depression that the pain brings, so I would say they have helped living a little some of the time but they ALL have lousy side effects of one sort or another, and eventually I have given up on them all when the drawbacks outweighed the benefits for me, (the time-scale for that has varied) and the depression is still there now [I am on none of them (for now!)] but everyone's "mileage" varies with any drug.

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