My father started venetoclax 1 week ago. He is a 71y/o, 17p CLL patient. He must be an inpatient at UPENN for fear of TLS for each ramp up week.
When he was admitted this Monday for week 2, his CBC showed a tremendous reduction in hemoglobin (currently at 7.8) and platelets (currently at 8000) His numbers were never great but while on a trial drug the past 12 months (TGR-1202), they usually hovered around 50-plates & 11.5-hemo.
Since Monday he has received 2 bags of blood and 3 bags of platelets, which have not produced better results. They held his venetoclax dose escalation yesterday and kept us at the 20mg dosage.
They are hoping to increase the dosage today to 50mg. They also now want us to do a bone marrow biopsy and it appears they are adding rituxin and a steroid to his treatment tomorrow. I was also told that this is now a day by day admission and we shouldn’t be expecting to be discharged anytime soon.
As you can imagine, I’m quite nervous about these results as this is the last option to treat him. While our outpatient oncology team is great at communicating, the inpatient team has left much to be desired, and I fear I’m not being told exactly what is happening and what we should expect.
Any help or information would be greatly appreciated.