What do we know about the HE4 Blood test as an additional monitoring tool for picking up recurrence as well as the standard CA125 test which is not a good indicator for some types of OC tumours? It would be interesting to get others feedback on this as it is used widely in USA for past 2 years as it works in a different way to CA125. My understanding is the HE4 picks up a protein that is only secreted when Ovarian Cancer cells are present whereas the CA125 just simply picks up on any inflammation present which may possibly be from other causes than Ovarian cancer tumours . That is the basic problem with an inflated CA125 figure, it can be caused by issues other than Ovarian cancer type inflammation.
Therefore it would seem to me that the HE4 is a good test to do ( its a simple blood test and we have enough of those already!) as anything that helps to pickup on an early recurrence is essential as an extra diagnostic tool. it would surely help the oncologists and ultimately us!