I have been put on Methotrexate in Jan 2013 at 10 mg, after having to many side effects with Prednisone !!. Feb 2013 the dosage was upped to 15 mg a week. I go back to my Dr March 8th. My question is? Are you supposed to get worse with this before you get better? I feel like I'm going back to square one!! Even though the MTX is helping with my knees some what. The rest of my body I don't feel a difference!! My neck, shoulders, and lower and rt hip have been killing me. Also do you usually have more pain on one side, worse then the other?