I have had 6 weeks of Methotrexate injections in total: 4 weeks in a row, then a gap of 2 weeks, then 2 more injections and now 2 weeks off. Have had permanent numbness in my right arm for about 2 months, the numbness in the leg started more recently. Keep getting terrible headaches with earache in my left ear, terrible problems with blurry vision and feeling dizzy (constant problem). Recently have been finding it hard to swallow also. Had a migraine with visual aura in early December. Have had x-rays, CT scan, MRI, the doctors have been baffled. Yesterday I wondered could it be drug-induced numbness and is it reversible? Has anyone else had any of these symptoms? I have RA, Ehlers-Danlos Syndrome type 3 hypermobility (connective tissue disorder) and suspected Sjogrens.