Methotrexate query

[cyprusmum]

Hi All,I started 15g Methotrexate injections 3 weeks ago. A variety of mini reactions, but expected. Nausea a bit, spots, but had a temp on Sat ( take it Wednesday evening), and feel a bit wheezy today. Has anybody had that when starting?

[Downtime]

I had nausea and stomach ache and a bit if a flare the following day when I started, but none of the symptoms you describe. Maybe a virus you’ve picked up ! Hope you feel better soon.

[Sheila_G]

I wouldn't expect mxt to give you a high temperature. It sounds like you have got something else going on as well.

[Runrig01]

You need to contact your rheumatologist asap. Methotrexate can cause lung issues like pneumonitis, which can present with a temperature and shortness of breath. I believe it’s only around 2% that get it, but it needs ruling out. I would certainly hold off on taking further till you speak with them. 🤗

[cba84]

I had nausea find it’s better if I inject it on an empty stomach. But none of the others best to give someone a ring to be safe good luck.

[Gnarli]

No temperature, spots or wheezing here. I'd do as Maureengibson suggests. I'm sure your rheumy team will be able to guide you as to the best way forward.

[Toffee1878]

Hi,

I take it orally and I find the side effects a bit inconsistent - mostly nausea, sometimes a very upset tum the day after but mostly absolute fatigue for the following 24 hours. And dreadful mouth ulcers at first (they threw extra folic acid on to combat that - not with 100% success!) I’m on 25mg at the moment but recently started anti TNF injections so hoping to reduce the methotrexate in the coming months.

Hope you do ok on it!

[cyprusmum in reply to Toffee1878]

Thanks, I eventually got through to Rheumy nurse, they stopped MTX for this week to see if the adverse reactions eased. Yes they did. I sent through photos of reactions etc. Waiting to see what Consultant comes back with.

Hope you do well on the new injections.