I have been having a rough go. I got really bad anxiety and depression approximately 2 months after my rituximab infusions. I don't know if this is as a result of the infusions as I got an informational pamphlet about rituximab and it mentioned mood changes and to tell your rheumy. But my rheumy says it's not from that. Has anyone else had this experience? And if so have u had to go on antidepressants? I've been on mirtazapine and had to come off due to high alt levels. Now I'm scared to try another antidepressant.