MTX orally stopped working after so long?

[Slightly_ginger]

Hi, I have PSA and cancer. I take Humira fortnightly (effects last 10days) I also take a small dose of steroids (2mg) when thing are really bad, yes I said 2mg. I get massive side effects with steroids.

Anyway my mum has been diagnosed with RD for 25 years and has been taking Mtx oral for most of it, she's 78 now and it seems the Mtx has lost its, efficacy, she takes 8x2.5mg of Mtx once a week. I've said to her she needs to look changing her medication as she is having continuous flare ups with little breaks, as opposed to controlled disease and odd flare up before.

Can Mtx lose its efficacy after such a long time? Your experience would be great so I could show her.

Lots of love and respect and best wishes to you all.

[sharon6768]

Has she talked to her rheumatologist about injections? I have no idea if the efficacy is any different, but it's worth the conversation. I opted for injections when I was on mtx because the mtx doesn't get processed through the liver. I preferred to have my liver damage from wine rather than mtx!