Diagnosed a year. Started off on Mtx but had to stop after 5 months as got horrendous migraines. I was then put on sulfasalazine which thankfully seems to agree with me. With my consultant we decided we would now try to add in Mtx starting slow and see how it goes. It really doesn't agree with me as well as having a fuzzy head most of each week the fatigue increased too. Also reflux didn't subside which was anothe issue I had with Mtx. So what has been the decider is this week. I didn't take Mtx this weekend as I had been suffering a cold and I have a busy week this week and the last thing I wanted was to feel rubbish. The end of last week I felt so rough. Today has been the most busy day ever at work and I feel great! Most Mondays I'm functioning and almost looking in on my life from the outside if that makes sense. It's like when you've had a few drinks and things start to slow down but everything around you is going fast. Then Tuesdays are normally my totally exhausted day. Hopefully that won't be the case. I feel a phone call to the nurses coming on.