Sulfasalazine causes depression?

[zrx1250]

Been on sulfazalazine 500 bid. Rhumy said Take 500 tid. Notice depression with the increase. Gonna go back to bid. Anyone else notice this ty

[woodstar1]

Hi, I've been absolutely fine on sulphasalazine, Methotrexate however caused a major head wobble and within a week or two of stopping I was absolutely back to normal. It's just goes to prove how differently we are when taking these meds. Have a chat with your nurse or consultant and get some advice, hope you feel better soon.

[nomoreheels]

I'm afraid it is a listed side effect & yes, I had a definite mood drop, change in personality. I can't honestly say it was depression because I'm aware that it really wasn't, certainly not depression as I've known it from others close to me but as my mood was altered so much I feared it would develop into something worse. I really didn't feel myself, I'm normally quite an easy going person but once I got up to 4 qid (I think, it wasn't a good time) & it didn't let up I insisted it was considered I reduced the dose. Even on 1 qd my mood wasn't lifting so I stopped. I had a break, just taking the one DMARD MTX (which I've taken 7 years) & the usual meds but have in the last month started leflunomide.

Please do discuss this with your Rheumy or nurse, if it is really affecting you now it could become a real problem a little further down the line. I was told it wasn't a side effect by my Rheumy nurse but I knew different & said so, it was a Registrar who eventually admitted it was & advised me to stop it straight away.

[Hidden]

I had a horrible time on sulfa. I had a psychotic episode whilst taking it, and had to come off asap. However, I am bipolar. That said lots of folks experience mood instability on sulfa.

[Philip]

I've been taking sulf for about 5 years and although i have depression its not come from sufa and im taking the Max dose.

Good for me.

Hood luck

[Jeanslmn]

I've been on four 500 sulfasalazine tablets for about six years not been depressed on them but do get depressed when having serious flare ups like now because there seems to be no end to the pains plus getting appointments or contacting RA unit where I live seems very difficult which does not help,

[Littlemunch]

I found it really efected my mood and recommend to stop by Dr and consultant. was a shame as it really helped.

[Scottishlad]

I never had any problems when on 6 tablets per day, only the yellow pee and yellow stains on my vests from the sweat. It is a shame that so many people are affected by side effects of drugs used to treat RA

[AllyWelshDragon]

I've been on it 5 years, and mtx the last 5 months as well. Touch-wood I've been fine with both so far.

Mind you I completely changed my diet and lost two stone so that helped. I'm 54 so I've been putting my occasional mood swings down to the menopause!

Hope you feel better soon

Ally x