Well after a long journey, 2 1/2 years, I have finally got my liver to a level where it can tolerate MTX & Imuran. I go on Monday to get the scripts and instructions, but I can tell you I am not looking forward to MTX as my sister had a really bad time on it and I have multiple chemical sensitivities so I am pretty much freaked out. What worries me is how I will cope working full time and feeling so bad on this stuff and I can't cut back my days as I would be homeless. My other problem is is that I have also fractured a bone in my ankle a week ago, which I am told will take a long time to heal, so i am slightly worried how they will affect the healing process. does anyone have any experience with having a fracture and being on these drugs?